OVGP1
Identifiers
Aliases	OVGP1, CHIT5, EGP, MUC9, OGP, oviductal glycoprotein 1
External IDs	OMIM: 603578 MGI: 106661 HomoloGene: 74442 GeneCards: OVGP1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.2 Start 111,414,319 bp[1] End 111,427,735 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.2 Start 105,881,027 bp[2] End 105,894,739 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube left uterine tube cerebellar hemisphere gastric mucosa right lobe of liver skin of abdomen Brodmann area 9 germinal epithelium nucleus accumbens putamen Top expressed in superior surface of tongue superior colliculus cingulate gyrus inferior colliculus uterine tube paraventricular nucleus of hypothalamus ventromedial nucleus dorsal tegmental nucleus medial geniculate nucleus arcuate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chitinase activity chitin binding Cellular component egg coat cytosol perivitelline space transport vesicle cytoplasmic vesicle extracellular region cytoplasm Biological process female pregnancy binding of sperm to zona pellucida negative regulation of binding of sperm to zona pellucida single fertilization chitin catabolic process carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5016 12659 Ensembl ENSG00000085465 ENSMUSG00000074340 UniProt Q12889 Q62010 RefSeq (mRNA) NM_002557 NM_007696 RefSeq (protein) NP_002548 NP_031722 Location (UCSC) Chr 1: 111.41 – 111.43 Mb Chr 3: 105.88 – 105.89 Mb PubMed search [3] [4]
Wikidata
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Oviduct-specific glycoprotein also known as oviductal glycoprotein (OGP) or estrogen-dependent oviduct protein, oviductin or mucin-9 is a protein that in humans is encoded by the OVGP1 gene.^[5][6][7]

Function

Oviduct-specific glycoprotein is a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoon acrosomal regions.^[7]

Beyond the oviduct, OVGP1 is detected in the mouse ovary, testis and epididymis suggesting its roles beyond fertilization. It is not detected in the mouse uterus, cervix, vagina, breast, seminal vesicles and prostate gland ^[8] OVGP1 is expressed by the surface epithelium of the endometrium at the time of embryo implantation in the mouse. It is required for maintain the receptivity phenotype and trophoblast adhesion, OVGP1 mRNA levels are reduced in endometrium of women with recurrent implantation failure.^[9]

References

Sources

Further reading

• Verhage HG, Fazleabas AT, Donnelly K (1988). "The in vitro synthesis and release of proteins by the human oviduct". Endocrinology. 122 (4): 1639–45. doi:10.1210/endo-122-4-1639. PMID 3278893.
• Iontcheva I, Oppenheim FG, Troxler RF (1997). "Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins". J. Dent. Res. 76 (3): 734–43. doi:10.1177/00220345970760030501. PMID 9109822. S2CID 39525421.
• Iontcheva I, Oppenheim FG, Offner GD, Troxler RF (2000). "Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system". J. Dent. Res. 79 (2): 732–9. doi:10.1177/00220345000790020601. PMID 10728974. S2CID 27558675.
• Agarwal A, Yeung WS, Lee KF (2002). "Cloning and characterization of the human oviduct-specific glycoprotein (HuOGP) gene promoter". Mol. Hum. Reprod. 8 (2): 167–75. doi:10.1093/molehr/8.2.167. PMID 11818519.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.{{cite journal}}: CS1 maint: overridden setting (link)
• Lok IH, Briton-Jones CM, Yuen PM, Haines CJ (2003). "Variable expression of oviductin mRNA at different stages of human reproductive cycle". J. Assist. Reprod. Genet. 19 (12): 569–76. doi:10.1023/A:1021263132176. PMC 3455833. PMID 12503889.
• Chen Q, Zhang J, Sweet F (2004). "Homology of primate DNA fragments for estrous-associated oviductal glycoprotein". Hereditas. 139 (1): 75–9. doi:10.1111/j.1601-5223.2003.01640.x. PMID 14641477.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.{{cite journal}}: CS1 maint: overridden setting (link)
• Woo MM, Alkushi A, Verhage HG, et al. (2005). "Gain of OGP, an estrogen-regulated oviduct-specific glycoprotein, is associated with the development of endometrial hyperplasia and endometrial cancer". Clin. Cancer Res. 10 (23): 7958–64. doi:10.1158/1078-0432.CCR-04-1261. PMID 15585630.{{cite journal}}: CS1 maint: overridden setting (link)
• Ling L, Lee YL, Lee KF, et al. (2006). "Expression of human oviductin in an immortalized human oviductal cell line". Fertil. Steril. 84 (Suppl 2): 1095–103. doi:10.1016/j.fertnstert.2005.06.006. PMID 16209999.{{cite journal}}: CS1 maint: overridden setting (link)
• Kadam KM, D'Souza SJ, Bandivdekar AH, Natraj U (2006). "Identification and characterization of oviductal glycoprotein-binding protein partner on gametes: epitopic similarity to non-muscle myosin IIA, MYH 9". Mol. Hum. Reprod. 12 (4): 275–82. doi:10.1093/molehr/gal028. PMID 16567366.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.{{cite journal}}: CS1 maint: overridden setting (link)