PI4KA
Identifiers
AliasesPI4KA, PI4K-ALPHA, PIK4CA, pi4K230, PMGYCHA, phosphatidylinositol 4-kinase alpha, SPG84, GIDID2
External IDsOMIM: 600286 MGI: 2448506 HomoloGene: 11171 GeneCards: PI4KA
Orthologs
SpeciesHumanMouse
Entrez

5297

224020

Ensembl

ENSG00000241973

ENSMUSG00000041720

UniProt

P42356

E9Q3L2

RefSeq (mRNA)

NM_002650
NM_058004
NM_001362862
NM_001362863

NM_001001983
NM_001373955

RefSeq (protein)

NP_477352
NP_001349791
NP_001349792

NP_001001983

Location (UCSC)Chr 22: 20.71 – 20.86 MbChr 16: 17.1 – 17.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Phosphatidylinositol 4-kinase alpha is an enzyme that in humans is encoded by the PI4KA gene.[5][6][7]

Function

This gene encodes a 1-phosphatidylinositol 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. Two transcript variants encoding different isoforms have been described for this gene.[7]

Clinical significance

The alpha isoform of PI4KIII plays a role in replication of hepatitis C virus (HCV).[8] Furthermore, the PI4KA lipid kinase affects HCV replication by altering phosphorylation of the HCV NS5A protein.[9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000241973 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041720 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wong K, Cantley LC (Dec 1994). "Cloning and characterization of a human phosphatidylinositol 4-kinase". J Biol Chem. 269 (46): 28878–84. doi:10.1016/S0021-9258(19)61989-7. PMID 7961848.
  6. Nakagawa T, Goto K, Kondo H (Aug 1996). "Cloning, expression, and localization of 230-kDa phosphatidylinositol 4-kinase". J Biol Chem. 271 (20): 12088–94. doi:10.1074/jbc.271.20.12088. PMID 8662589.
  7. 1 2 "Entrez Gene: PIK4CA phosphatidylinositol 4-kinase, catalytic, alpha polypeptide".
  8. Reiss S, Rebhan I, Backes P, Romero-Brey I, Erfle H, Matula P, Kaderali L, Poenisch M, Blankenburg H, Hiet MS, Longerich T, Diehl S, Ramirez F, Balla T, Rohr K, Kaul A, Bühler S, Pepperkok R, Lengauer T, Albrecht M, Eils R, Schirmacher P, Lohmann V, Bartenschlager R (January 2011). "Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment". Cell Host Microbe. 9 (1): 32–45. doi:10.1016/j.chom.2010.12.002. PMC 3433060. PMID 21238945.
  9. Reiss S, Harak C, Romero-Brey I, Radujkovic D, Klein R, Ruggieri A, Rebhan I, Bartenschlager R, Lohmann V (May 2013). "The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5A". PLOS Pathog. 9 (5): e1003359. doi:10.1371/journal.ppat.1003359. PMC 3649985. PMID 23675303.

Further reading

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