POLR3G

POLR3G
Identifiers
Aliases	POLR3G, RPC32, RPC7, polymerase (RNA) III subunit G, RNA polymerase III subunit G, C31
External IDs	OMIM: 617456 MGI: 1914736 HomoloGene: 38184 GeneCards: POLR3G
Gene location (Human)
Chr.	Chromosome 5 (human)
End	90,514,557 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	81,859,132 bp
RNA expression pattern
	Top expressed in
	spinal ganglia; ; sural nerve; ; secondary oocyte; ; internal globus pallidus; ; monocyte; ; trigeminal ganglion; ; cerebellar hemisphere; ; substantia nigra; ; pancreatic ductal cell; ; stromal cell of endometrium;
	Top expressed in
	morula; ; primitive streak; ; esophagus; ; facial motor nucleus; ; yolk sac; ; urothelium; ; epidermis; ; lip; ; hair follicle; ; renal corpuscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-directed 5'-3' RNA polymerase activity; protein binding;
Cellular component	RNA polymerase III complex; cytosol; nucleoplasm; nucleus; cytoplasm;
Biological process	positive regulation of interferon-beta production; immune system process; cell population proliferation; defense response to virus; positive regulation of innate immune response; innate immune response; regulation of transcription by RNA polymerase III; transcription by RNA polymerase III; positive regulation of type I interferon production;
	Sources:Amigo / QuickGO
Orthologs
	10622
	67486
	ENSG00000113356
	ENSMUSG00000035834
	O15318
	Q6NXY9
	NM_006467; NM_001370351; NM_001370352; NM_001370353; NM_001370354
	NM_001081176; NM_026190
	NP_006458; NP_001357280; NP_001357281; NP_001357282; NP_001357283
	NP_001074645
	Wikidata
View/Edit Human	View/Edit Mouse

Polymerase (RNA) III (DNA directed) polypeptide G (32kD) is a protein that in humans is encoded by the POLR3G gene. ^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000113356 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035834 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Polymerase (RNA) III (DNA directed) polypeptide G (32kD)". Retrieved 2014-04-01.

Ablasser A, Bauernfeind F, Hartmann G, Latz E, Fitzgerald KA, Hornung V (October 2009). "RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate". Nature Immunology. 10 (10): 1065–1072. doi:10.1038/ni.1779. PMC 3878616. PMID 19609254.
Chiu YH, Macmillan JB, Chen ZJ (August 2009). "RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway". Cell. 138 (3): 576–591. doi:10.1016/j.cell.2009.06.015. PMC 2747301. PMID 19631370.
Chantarangsu S, Mushiroda T, Mahasirimongkol S, Kiertiburanakul S, Sungkanuparph S, Manosuthi W, et al. (August 2011). "Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash". Clinical Infectious Diseases. 53 (4): 341–348. doi:10.1093/cid/cir403. PMID 21810746.
Wong RC, Pollan S, Fong H, Ibrahim A, Smith EL, Ho M, et al. (October 2011). "A novel role for an RNA polymerase III subunit POLR3G in regulating pluripotency in human embryonic stem cells". Stem Cells. 29 (10): 1517–1527. doi:10.1002/stem.714. PMID 21898682. S2CID 24305950.
Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". Journal of Acquired Immune Deficiency Syndromes. 5 (11): 1142–1147. PMID 1403646.
Wang Z, Roeder RG (May 1997). "Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation". Genes & Development. 11 (10): 1315–1326. doi:10.1101/gad.11.10.1315. PMID 9171375.
Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N (November 2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits". Molecular and Cellular Biology. 22 (22): 8044–8055. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740. PMID 12391170.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000113356 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035834 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Polymerase (RNA) III (DNA directed) polypeptide G (32kD)". Retrieved 2014-04-01.

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References

Further reading