PPP2R2C
Identifiers
AliasesPPP2R2C, B55-GAMMA, IMYPNO, IMYPNO1, PR52, PR55G, protein phosphatase 2 regulatory subunit Bgamma, B55gamma
External IDsOMIM: 605997 MGI: 2442660 HomoloGene: 36386 GeneCards: PPP2R2C
Orthologs
SpeciesHumanMouse
Entrez

5522

269643

Ensembl

ENSG00000074211

ENSMUSG00000029120

UniProt

Q9Y2T4

Q8BG02

RefSeq (mRNA)

NM_172994
NM_001360003

RefSeq (protein)

NP_766582
NP_001346932

Location (UCSC)Chr 4: 6.32 – 6.56 MbChr 5: 37.03 – 37.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform is an enzyme that in humans is encoded by the PPP2R2C gene.[5][6][7]

Function

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000074211 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029120 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Torres R, Ide SE, Dehejia A, Baras A, Polymeropoulos MH (Oct 1999). "Genomic structure and localization of the human protein phosphatase 2A BRgamma regulatory subunit". DNA Research. 6 (5): 323–7. CiteSeerX 10.1.1.575.4908. doi:10.1093/dnares/6.5.323. PMID 10574460.
  6. Hu P, Yu L, Zhang M, Zheng L, Zhao Y, Fu Q, Zhao S (Jul 2000). "Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16". Genomics. 67 (1): 83–6. doi:10.1006/geno.2000.6219. PMID 10945473.
  7. 1 2 "Entrez Gene: PPP2R2C protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform".

Further reading

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