PPP2R5A
Identifiers
AliasesPPP2R5A, B56A, PR61A, protein phosphatase 2 regulatory subunit B'alpha, B56alpha
External IDsOMIM: 601643 MGI: 2388479 HomoloGene: 55961 GeneCards: PPP2R5A
Orthologs
SpeciesHumanMouse
Entrez

5525

226849

Ensembl

ENSG00000066027

ENSMUSG00000026626

UniProt

Q15172

Q6PD03

RefSeq (mRNA)

NM_006243
NM_001199756

NM_144880

RefSeq (protein)

NP_001186685
NP_006234

NP_659129

Location (UCSC)Chr 1: 212.29 – 212.36 MbChr 1: 191.08 – 191.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform is an enzyme that in humans is encoded by the PPP2R5A gene.[5]

Function

The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily.[6]

Interactions

PPP2R5A has been shown to interact with:

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000066027 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026626 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. McCright B, Virshup DM (Nov 1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". The Journal of Biological Chemistry. 270 (44): 26123–8. doi:10.1074/jbc.270.44.26123. PMID 7592815.
  6. "Entrez Gene: PPP2R5A protein phosphatase 2, regulatory subunit B', alpha isoform".
  7. Yamamoto H, Hinoi T, Michiue T, Fukui A, Usui H, Janssens V, Van Hoof C, Goris J, Asashima M, Kikuchi A (Jul 2001). "Inhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2A". The Journal of Biological Chemistry. 276 (29): 26875–82. doi:10.1074/jbc.M100443200. PMID 11297546.
  8. Baroja ML, Vijayakrishnan L, Bettelli E, Darlington PJ, Chau TA, Ling V, Collins M, Carreno BM, Madrenas J, Kuchroo VK (May 2002). "Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A". Journal of Immunology. 168 (10): 5070–8. doi:10.4049/jimmunol.168.10.5070. PMID 11994459.
  9. 1 2 3 Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
  10. 1 2 McCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". The Journal of Biological Chemistry. 271 (36): 22081–9. doi:10.1074/jbc.271.36.22081. PMID 8703017.
  11. 1 2 Zhou J, Pham HT, Ruediger R, Walter G (Jan 2003). "Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution". The Biochemical Journal. 369 (Pt 2): 387–98. doi:10.1042/BJ20021244. PMC 1223084. PMID 12370081.
  12. 1 2 Strack S, Ruediger R, Walter G, Dagda RK, Barwacz CA, Cribbs JT (Jun 2002). "Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits". The Journal of Biological Chemistry. 277 (23): 20750–5. doi:10.1074/jbc.M202992200. PMID 11929880.

Further reading


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