PRKX

PRKX
Identifiers
Aliases	PRKX, PKX1, protein kinase, X-linked, protein kinase X-linked
External IDs	OMIM: 300083 MGI: 1309999 HomoloGene: 55868 GeneCards: PRKX
Gene location (Human)
Chr.	X chromosome (human)
End	3,713,649 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	76,839,884 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; monocyte; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; right uterine tube; ; skin of abdomen; ; endometrium; ; right lung; ; vagina; ; tibial nerve;
	Top expressed in
	olfactory epithelium; ; ascending aorta; ; aortic valve; ; trigeminal ganglion; ; blood; ; conjunctival fornix; ; submandibular gland; ; intestinal villus; ; pyloric antrum; ; sciatic nerve;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; cAMP-dependent protein kinase activity; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding;
Cellular component	cytoplasm; nucleus;
Biological process	myeloid cell differentiation; cell differentiation; regulation of cell migration; phosphorylation; epithelial tube morphogenesis; multicellular organism development; protein phosphorylation; cell-substrate adhesion; regulation of cell adhesion; cell adhesion; peptidyl-serine phosphorylation; endothelial cell proliferation; kidney morphogenesis; angiogenesis; protein autophosphorylation; endothelial cell migration; regulation of epithelial cell differentiation involved in kidney development;
	Sources:Amigo / QuickGO
Orthologs
	5613
	19108
	ENSG00000183943
	ENSMUSG00000035725
	P51817
	Q922R0
	NM_005044
	NM_016979
	NP_005035; NP_005035.1
	NP_058675
	Wikidata
View/Edit Human	View/Edit Mouse

Protein kinase, X-linked is a protein that in humans is encoded by the PRKX gene. ^[5]

Function

This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y.

Nomenclature

Mouse ortholog for this gene, Prkx, is also known as Pkare.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000183943 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035725 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Protein kinase, X-linked". Retrieved 2017-05-19.
↑ "Prkx protein kinase, X-linked [ Mus musculus (house mouse) ]". National Center for Biotechnology Information.

Li X, Li HP, Amsler K, Hyink D, Wilson PD, Burrow CR (2002). "PRKX, a phylogenetically and functionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9260–5. Bibcode:2002PNAS...99.9260L. doi:10.1073/pnas.132051799. PMC 123128. PMID 12082174.
Li X, Burrow CR, Polgar K, Hyink DP, Gusella GL, Wilson PD (2008). "Protein kinase X (PRKX) can rescue the effects of polycystic kidney disease-1 gene (PKD1) deficiency" (PDF). Biochim. Biophys. Acta. 1782 (1): 1–9. doi:10.1016/j.bbadis.2007.09.003. PMID 17980165. S2CID 23224610.
Li X, Iomini C, Hyink D, Wilson PD (2011). "PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation". Dev. Biol. 356 (2): 475–85. doi:10.1016/j.ydbio.2011.05.673. PMID 21684272.
Lin Y, Li W (2011). "MBD 4--a potential substrate for protein kinase X". Acta Biochim. Biophys. Sin. (Shanghai). 43 (11): 916–7. doi:10.1093/abbs/gmr086. PMID 21971312.
Bender C, Ullrich A (2012). "PRKX, TTBK2 and RSK4 expression causes Sunitinib resistance in kidney carcinoma- and melanoma-cell lines". Int. J. Cancer. 131 (2): E45–55. doi:10.1002/ijc.26486. PMID 22020623. S2CID 27590197.
Huang S, Li Q, Alberts I, Li X (2016). "PRKX, a Novel cAMP-Dependent Protein Kinase Member, Plays an Important Role in Development". J. Cell. Biochem. 117 (3): 566–73. doi:10.1002/jcb.25304. PMID 26252946. S2CID 45734891.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000183943 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035725 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Protein kinase, X-linked". Retrieved 2017-05-19.

[6] "Prkx protein kinase, X-linked [ Mus musculus (house mouse) ]". National Center for Biotechnology Information.

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Function

Nomenclature

References

Further reading