PRSS3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRSS3, MTG, PRSS4, T9, TRY3, TRY4, protease, serine 3, serine protease 3
External IDsOMIM: 613578 MGI: 102757 HomoloGene: 106639 GeneCards: PRSS3
Orthologs
SpeciesHumanMouse
Entrez

5646

22074

Ensembl

ENSG00000010438

ENSMUSG00000054106

UniProt

P35030

Q9R0T7

RefSeq (mRNA)

NM_001197097
NM_001197098
NM_002771
NM_007343

NM_011646

RefSeq (protein)

NP_001184026
NP_001184027
NP_002762
NP_031369

NP_035776

Location (UCSC)Chr 9: 33.75 – 33.8 MbChr 6: 41.28 – 41.28 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protease, serine, 3 is a protein that in humans is encoded by the PRSS3 gene.[5]

Function

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000010438 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054106 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Protease, serine, 3".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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