The PTS Galactitol (Gat) Family (TC# 4.A.5) is part of the PTS-AG superfamily. The biochemistry of this family is poorly defined. The only well-characterized member of this family is the galactitol permease of Escherichia coli.[1] However, a homologous IIC protein from Listeria monocytogenes has been shown to be required for D-arabitol fermentation.[2] It presumably functions together with IIAGat and IIBGat homologues. IICGat is distantly related to IICSgc of E. coli; IIAGat is distantly related to IIASga and IIASgcof E. coli as well as IIAMtl and IIAFru. IIBGat is distantly related to IIBSga and IIBSgc of E. coli.[3] Domains in the LicR/CelR family of transcriptional activators show C-terminal domains exhibiting weak sequence similarity to IIBGat and IIAGat.[4]

References

  1. ↑ Nobelmann, Barbara (17 May 1995). "Sequence of the gat operon for galactitol utilization from a wild-type strain EC3132 of Escherichia coli". Biochim Biophys Acta. 1262 (1): 69–72. doi:10.1016/0167-4781(95)00053-j. PMID 7772602.
  2. ↑ Saklani-Jusforgues, H.; Fontan, E.; Goossens, P. L. (2001-03-01). "Characterisation of a Listeria monocytogenes mutant deficient in D-arabitol fermentation". Research in Microbiology. 152 (2): 175–177. doi:10.1016/s0923-2508(01)01189-5. ISSN 0923-2508. PMID 11316371.
  3. ↑ Reizer, Jonathan (Apr 1995). "Novel phosphotransferase system genes revealed by bacterial genome analysis--a gene cluster encoding a unique Enzyme I and the proteins of a fructose-like permease system". Microbiology. 141 (4): 961–71. doi:10.1099/13500872-141-4-961. PMID 7773398.
  4. ↑ Tchieu, J. H.; Norris, V.; Edwards, J. S.; Saier, M. H. (2001-07-01). "The complete phosphotransferase system in Escherichia coli". Journal of Molecular Microbiology and Biotechnology. 3 (3): 329–346. ISSN 1464-1801. PMID 11361063.

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