The medication paracetamol (INN) (/ˌpærəˈstəmɒl/ or /ˌpærəˈsɛtəmɒl/), also known as acetaminophen (USAN) (/əˌstəˈmɪnəfɪn/ ), is sold around the world under a number of different brand names. Common brand names include Tylenol, Excedrin, Calpol, and Panadol.

Tylenol

Tylenol 8-hour pills

Tylenol is a brand of drugs advertised for reducing pain, reducing fever, and relieving the symptoms of allergies, cold, cough headache, and influenza. The active ingredient of its original flagship product is paracetamol. The brand name "Tylenol" is owned by McNeil Consumer Healthcare,[1] a subsidiary of Kenvue. As of 2017 the brand was used in Brazil, Canada, China, Egypt, Lebanon, Myanmar, Oman, Philippines, Portugal, Switzerland, Thailand, United States, and Vietnam.[2]

Calpol

Calpol is a brand of children's medicine sold in the UK, Ireland, India, Cyprus, Hong Kong, Kenya, Malta, Philippines and Turkey. The main product is a paracetamol suspension, branded as Calpol Infant Suspension. It is usually a coloured syrup with a sweet taste, and is used to treat fever and pain. In 2016 it was the second biggest selling branded over-the-counter medication sold in Great Britain, with sales of £66.3 million.[3]

Calpol also comes in a form containing ibuprofen, marketed under the name Calprofen. Calpol is a common cause of accidental child poisoning because of its pleasant taste.[4] Calpol Night, a product containing paracetamol and an anti-histamine, was listed for use from 2+ months. However, this was changed and it is now only considered suitable for children over the age of 6 years.[5]

History

Calpol was launched in 1959 by English pharmaceutical company, Calmic Ltd, based in Crewe, Cheshire; the company's name was an abbreviation of Cheshire and Lancashire Medical Industries Corporation, which moved from Lancashire to Crewe Hall in 1947.[6] The Calpol brand name is likely a combination of 'Calmic' and 'paracetamol'.[7] Calmic was acquired by Wellcome (today GlaxoSmithKline) in 1966, and Calpol became one of Wellcome's best-selling UK products in the 1980s.[7] The brand was later owned by Pfizer Consumer Healthcare, which was acquired by Johnson & Johnson in 2006.[8] Calpol is today a brand of Johnson & Johnson's McNeil Consumer Healthcare subsidiary; in 2020, Calpol was the UK's top-selling paediatric analgesic product with sales worth £60.1 million.[9]

Panadol

Panadol 500 mg tablets

Panadol is one of GlaxoSmithKline's trade names for paracetamol or acetaminophen. According to GlaxoSmithKline, Panadol is marketed in 85 countries,[10] including Australia,[11] Bahrain, Belgium,[12] Brazil,[12] Bulgaria,[12] Chile,[12] Egypt, Finland,[12] France,[12] Greece,[12] Honduras, Hong Kong,[12] Indonesia,[12] Ireland,[12] Italy,[12] Kenya,[12] Korea,[12] Lebanon, Malaysia, Netherlands,[12] New Zealand,[13] Nigeria,[14] the Philippines,[12] Peru,[12] Puerto Rico,[10] Pakistan, Qatar, Romania, Saudi Arabia, Singapore, South Africa,[12] Sri Lanka, Switzerland,[12] Taiwan,[12] Thailand, Trinidad and Tobago, Turkey, the United Arab Emirates,[12] the United Kingdom, Vietnam, Malta, Uruguay, North Korea[12] and Oman.

History

After it was first introduced only in clinics in 1953, Panadol started its commercial business in 1955 by Phillips, Scott & Turner, which was acquired by Frederick Stearns & Co, a subsidiary of Sterling Drug Inc. It was advertised as being "gentle on the stomach", since other analgesic agents at the time contained aspirin, a known stomach irritant. In 1955, Panadol was introduced to hospitals in the United Kingdom.[15] Panadol was originally available only by prescription in the UK, but is now available over the counter. In 1983, Sterling introduced Panadol to the United States market.[16] In 1988 Sterling Winthrop was acquired by Eastman Kodak which sold the worldwide over the counter drug business to SmithKline Beecham in 1994.[17] Two weeks later, SmithKline Beecham sold the over-the-counter medication business in the United States, Canada and Puerto Rico to Bayer for US$1 billion.[18] However, North American rights to Panadol were retained by SmithKline.[18] It has been called "one of the most-frequently counterfeited medicines in the world."[19]

Other formulations and packaging

Panadol is sold in different formulations and packaging with different names.[10][20]

Panadol Extra, an S2 pharmacy-only medicine in Australia, combines 65 mg of caffeine with 500 mg of paracetamol per tablet. Caffeine may improve the analgesic effect of paracetamol. Studies have reached conflicting conclusions regarding the clinical significance of this incremental pain relief.[21][22]

Panadol Osteo and Panadol Extend Tablets are modified-release formulations of paracetamol.[23] Panadol Osteo is marketed in Australia and New Zealand; its immediate to sustained release ratio is 33% to 66%.[24]

Panadol Rapid Handipak is Panadol Rapid packaged in a slim container of ten 500 mg caplets, designed to appeal to Australian women who are 20 to 35 years of age.[25][26]

Panadol Cold and Catarrh contains three active ingredients: paracetamol, phenylephrine hydrochloride as a nasal decongestant, and chlorpheniramine maleate to prevent certain allergies.[20]

Panadol Cold and Flu and Panadol Fever and Congestion both combine paracetamol with phenylephrine hydrochloride as a nasal decongestant.[13][27]

Other brand names

Common brand names include:[28]
Brand name Countries
Acamol Israel
Ace + Bangladesh
Acet United States
Acetalgin Switzerland
Adol Bahrain, Kuwait, Oman, United Arab Emirates
Aeknil[29] India
Aldolor Israel
Alvedon Sweden
APAP Poland, Greenland, United States
Apiretal
Apiretal Flas
Spain, Portugal
Atamel Venezuela, Haiti
Atasol Canada, Mexico
Benuron Austria, Germany, Portugal, Switzerland
Biogesic Myanmar, Philippines, Indonesia
Biogesic-Kiddielets Myanmar
Buscapina Argentina, Mexico, Spain, Venezuela
Calonal Japan[30]
Calpol Bulgaria, Cyprus, India, Ireland, Kenya, Turkey, United Kingdom, Philippines, Pakistan, South Africa
Captin Germany
Cemol Thailand
Cetamol Nepal
Coldex Israel
Coldrex Bulgaria, Croatia, Estonia, Romania, Slovenia
Co-Tipol Ireland (with Codeine Phosphate Hemihydrate)
Cotibin Chile
Crocin India
Dafalgan Belgium, France, Portugal, Russia, Spain (Esteve), Switzerland, Ukraine
Daleron Slovenia, North Macedonia
Depon Greece, Cyprus
Dexamol
Dexamol Plus
Israel
Dolex Colombia
Dolgesic Spain (Ferrer Grupo)
Doli-Bien Algeria
Doliprane Algeria, France, Morocco, Portugal, Russia, Tunisia, Ukraine, Senegal, Mali, Ivory Coast
Dolo India
Dolorol South Africa
Dolprone Switzerland
Dolyc Algeria
Duiyixian anjifen pian (Chinese: 对乙酰氨基酚片; lit. 'Acetaminophen Tablets') China
Efferalgan Bulgaria, Croatia, Estonia, France, Italy, Portugal, Romania, Russia, Serbia, Spain, Ukraine, Vietnam. Made by UPSA Laboratoires in France. CoEfferalgan instead is a preparation of paracetamol and codeine and follows the restrictions placed on opioid analgesics.
Endopain Hong Kong
Enelfa Germany
Europain Hong Kong
Excedrin Brazil, Canada, Japan, Mexico, Myanmar, Panama, Puerto Rico, Peru, South Korea, Switzerland, Thailand, United States (combined with Aspirin and Caffeine). Formerly marketed in Ireland.
Expandol Algeria
Febrectal Spain (Almirall)
Febricet Serbia
Febridol Australia
Fensum Germany
Fepanil India
Fervex Bulgaria
Fevadol Saudi Arabia
Gelocatil Spain (Gelos)
Gripin Turkey
Gesic Bangladesh
Hedex Bangladesh, Kenya
Hedanol Australia
Herron Australia
Influbene Switzerland
Kafa Switzerland
Kitadol Chile
Lekadol Croatia, Slovenia
Lupocet Croatia
Metacin India
Mexalen Austria
Milidon Malaysia
Minoset Turkey
Momentum Austria
Napa Bangladesh
NapaDol Bangladesh (Paracetamol + Tramadol)
Niko Nepal
Neo-Kiddielets Philippines
Pain Relief United States, Australia
Pacol Georgia
Pamol Denmark, Estonia, Finland, France, New Zealand, Norway, Sweden, Indonesia
Panado South Africa
Panadol Afghanistan, Algeria, Australia, Azerbaijan, Bahrain, Belgium, Bulgaria, British West Indies, Central America, Chile, Croatia, Cyprus, Czech Republic, Egypt, Estonia, Finland, Greece, Hong Kong, Hungary, Indonesia, Ireland, Kenya, Kuwait, Jordan, Lebanon, Lithuania, North Macedonia, Malaysia, Malta, Myanmar, Netherlands, New Zealand, Nigeria, Oman, Pakistan, Panama, Peru, Poland, Portugal, Puerto Rico, Qatar, Romania, Russia, Saudi Arabia, Serbia, Singapore, Slovakia, Slovenia, Sri Lanka, Switzerland, Syria, Taiwan, Tanzania, Turkey, Uganda, Ukraine, United Arab Emirates, United Kingdom, United States, Vietnam
Panamax Australia
Panda Jordan[31]
Panodil Denmark, Iceland, Norway, Sweden
Paracet Norway, Serbia
Paracetamol Albania, Australia, Bosnia, Croatia, Serbia
Paracitol Sri Lanka
Paralen Czech Republic, Slovakia
Paralgan Algeria
Paramax Finland, Estonia
Paramed Botswana, South Africa, Zimbabwe
Paratabs Iceland
Paramol Algeria, Israel, Taiwan, United Kingdom (contains paracetamol and dihydrocodeine tartrate)
Paracetol Iraq
Parol Turkey
Perdolan Belgium
Perfalgan Estonia, Germany, Norway, Spain, South Africa (Bristol-Myers Squibb), Switzerland
Pinex Denmark, Iceland, Norway, Finland
Piretanyl Chile, Israel, Netherlands, Turkey
Plicet Croatia
PyongSu Cetamol North Korea
Pyrenol (Paracetamol plus caffeine) Bangladesh
Pyrigesic India
Reliv Sweden
Revanin Jordan
Rokamol Israel
Rubophen Hungary
Sanmol Indonesia
Sara Thailand
Scanol Taiwan
Sinpro N Germany
Tachipirin Venezuela
Tachipirina Italy, Albania
Tafirol Argentina, Mexico
Tapsin Chile
Termalgin Spain (Novartis)
Tempra Mexico, Philippines, Indonesia, Venezuela
Thomapyrin Austria, Germany (contains Paracetamol, Acetylsalicylic acid and Caffeine)
Tipol Ireland
Togal Classic Duo Germany (contains Paracetamol and Acetylsalicylic acid)
Treuphadol Switzerland
Triaminic United States
Tylenol Brazil, Canada, China, Japan, Mexico, Myanmar, Panama, Peru, Philippines, Puerto Rico, South Korea, Switzerland, Thailand, United States. Formerly marketed in Ireland.
Uphamol Malaysia
Vermidon Turkey
Vitamol Thailand
Xumadol Spain (Italfarmaco)
Zolben Switzerland, Uruguay, Chile.

References

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  15. GlaxoSmithKline | Panadol 50 Years
  16. Hollie, Pamela G. (14 March 1983). "Sterling to Try Again with a Nonaspirin Drug". New York Times. Retrieved 20 May 2015.
  17. SEC Info| Eastman Kodak Co | 8-K | For 6/30/94
  18. 1 2 Olmos, David R. (13 Sep 1994). "German Firm to Reclaim Bayer Aspirin Name : Drugs: It will acquire Sterling Winthrop's over-the-counter business and recover the rights it lost after WWI". The Los Angeles Times. Retrieved 25 May 2017.
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  28. drugs.com Drugs.com International Listings for Paracetamol Page accessed May 21, 2015
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