Professor Patrick Humphrey

OBE
EducationUniversity of London
Known forDiscovery of the triptans
AwardsCameron Prize for Therapeutics of the University of Edinburgh (1996)
Scientific career
Doctoral advisorRichard Creese

Professor Patrick Humphrey OBE DSc PhD HonFBPhS is a South African-born British pharmacologist.[1] He was instrumental in the discovery of the triptans, a group of 5-HT1B and 5-HT1D agonists[2] used to stop single instances of cluster headache or migraine.

Career

Patrick Humphrey studied at the University of London for his undergraduate, master's and doctoral degrees. His doctoral thesis concerned the activities of decamethonium at the neuromuscular junction, and was supervised by Richard Creese.[1] After his PhD, Patrick joined Allen & Hanburys, a subsidiary of GlaxoSmithKline. His research into the cerebrovascular system uncovered some mechanisms by which serotonergic drugs affected blood flow within the skull. This led to the discovery of the triptans, a group of 5-HT1B/1D agonists, most notably sumatriptan. He then became the director of the Glaxo Division of Pharmacology, which would go on to develop the anti-emetic drug odansetron. At this time he was also made an honorary Professor of Applied Pharmacology by the University of Cambridge.[1] From 2001–2008, he acted as Head of Research at Theravance.[3]

Awards

In 1996, Patrick was awarded the Cameron Prize for Therapeutics of the University of Edinburgh. The next year, 1997, he was awarded the Royal Society's Mullard Award.[4] He was awarded the OBE for "services to migraine research".[3]

References

  1. 1 2 3 Tansey EM, Yabsley A, Humphrey P (2016). Becoming a pharmacologist: The School of Pharmacy and St. Mary’s. History of Modern Biomedicine Interviews (Digital Collection), item e2016022. London: Queen Mary University of London. doi: 10.17636/01012988
  2. ↑ Tepper, Stewart J.; Rapoport, Alan M.; Sheftell, Fred D. (2002-07-01). "Mechanisms of Action of the 5-HT1B/1D Receptor Agonists". Archives of Neurology. 59 (7): 1084–8. doi:10.1001/archneur.59.7.1084. ISSN 0003-9942. PMID 12117355.
  3. 1 2 "Dr Patrick Humphrey OBE". British Pharmacological Society.
  4. ↑ "Discussion". Trends in Pharmacological Sciences. 18 (9): 306–307. 1997. doi:10.1016/S0165-6147(97)01098-5.
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