CBY1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCBY1, C22orf2, CBY, HS508I15A, PGEA1, PIGEA-14, PIGEA14, arb1, chibby homolog 1 (Drosophila), chibby family member 1, beta catenin antagonist, Chibby1
External IDsOMIM: 607757 MGI: 1920989 HomoloGene: 12514 GeneCards: CBY1
Orthologs
SpeciesHumanMouse
Entrez

25776

73739

Ensembl

ENSG00000100211

ENSMUSG00000022428

UniProt

Q9Y3M2

Q9D1C2

RefSeq (mRNA)

NM_015373
NM_001002880

NM_028634

RefSeq (protein)

NP_001002880
NP_056188

NP_082910

Location (UCSC)Chr 22: 38.66 – 38.67 MbChr 15: 79.54 – 79.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein chibby homolog 1 is a protein that in humans is encoded by the CBY1 gene.[5][6][7]

Function

Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.[7]

Interactions

CBY1 has been shown to interact with Beta-catenin.[8] CBY1 has also been shown to interact with CEP164, CIBAR1 (FAM92A1), and RAB8A.[9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000100211 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022428 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  6. Hidaka S, Könecke V, Osten L, Witzgall R (Aug 2004). "PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2". J Biol Chem. 279 (33): 35009–16. doi:10.1074/jbc.M314206200. PMID 15194699.
  7. 1 2 "Entrez Gene: CBY1 chibby homolog 1 (Drosophila)".
  8. Takemaru K, Yamaguchi S, Lee YS, Zhang Y, Carthew RW, Moon RT (Apr 2003). "Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathway". Nature. 422 (6934): 905–9. Bibcode:2003Natur.422..905T. doi:10.1038/nature01570. PMID 12712206. S2CID 4418716.
  9. Li FQ, Chen X, Fisher C, Siller SS, Zelikman K, Kuriyama R, Takemaru KI (November 2016). "BAR Domain-Containing FAM92 Proteins Interact with Chibby1 To Facilitate Ciliogenesis". Molecular and Cellular Biology. 36 (21): 2668–2680. doi:10.1128/MCB.00160-16. PMC 5064215. PMID 27528616.

Further reading


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