RASD2
Identifiers
AliasesRASD2, MGC:4834, Rhes, TEM2, RASD family member 2
External IDsOMIM: 612842 MGI: 1922391 HomoloGene: 8628 GeneCards: RASD2
Orthologs
SpeciesHumanMouse
Entrez

23551

75141

Ensembl

ENSG00000100302

ENSMUSG00000034472

UniProt

Q96D21

P63032

RefSeq (mRNA)

NM_014310
NM_001366725
NM_001376515
NM_001376516

NM_029182

RefSeq (protein)

NP_055125
NP_001353654
NP_001363444
NP_001363445

NP_083458

Location (UCSC)Chr 22: 35.54 – 35.55 MbChr 8: 75.94 – 75.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GTP-binding protein Rhes is a protein that in humans is encoded by the RASD2 gene.[5][6][7][8]

This gene encodes a Ras-related protein that is produced largely in the striatum. The product of this gene binds to GTP and possesses intrinsic GTPase activity. The gene belongs to the Ras superfamily of small GTPases. The exact function of this gene is unknown, but most striatum-specific mRNAs characterized to date encode components of signal transduction cascades.[8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000100302 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034472 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. St Croix B, Rago C, Velculescu V, Traverso G, Romans KE, Montgomery E, Lal A, Riggins GJ, Lengauer C, Vogelstein B, Kinzler KW (Aug 2000). "Genes expressed in human tumor endothelium". Science. 289 (5482): 1197–202. Bibcode:2000Sci...289.1197S. doi:10.1126/science.289.5482.1197. PMID 10947988.
  6. Falk JD, Vargiu P, Foye PE, Usui H, Perez J, Danielson PE, Lerner DL, Bernal J, Sutcliffe JG (Oct 1999). "Rhes: A striatal-specific Ras homolog related to Dexras1". J Neurosci Res. 57 (6): 782–8. doi:10.1002/(SICI)1097-4547(19990915)57:6<782::AID-JNR3>3.0.CO;2-9. PMID 10467249. S2CID 21124545.
  7. Vargiu P, De Abajo R, Garcia-Ranea JA, Valencia A, Santisteban P, Crespo P, Bernal J (Jan 2004). "The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors". Oncogene. 23 (2): 559–68. doi:10.1038/sj.onc.1207161. PMID 14724584.
  8. 1 2 "Entrez Gene: RASD2 RASD family, member 2".

Further reading


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