RBMS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRBMS1, C2orf12, HCC-4, MSSP, MSSP-1, MSSP-2, MSSP-3, SCR2, YC1, RNA binding motif single stranded interacting protein 1
External IDsOMIM: 602310 MGI: 1861774 HomoloGene: 9640 GeneCards: RBMS1
Orthologs
SpeciesHumanMouse
Entrez

5937

56878

Ensembl

ENSG00000153250

ENSMUSG00000026970

UniProt

P29558

Q91W59

RefSeq (mRNA)

NM_002897
NM_016836
NM_016839

NM_001141931
NM_001141932
NM_020296

RefSeq (protein)

NP_002888
NP_058520

NP_001135403
NP_001135404
NP_064692

Location (UCSC)Chr 2: 160.27 – 160.49 MbChr 2: 60.58 – 60.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RNA-binding motif, single-stranded-interacting protein 1 is a protein that in humans is encoded by the RBMS1 gene.[5][6][7][8]

Function

This gene encodes a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. Multiple transcript variants, resulting from alternative splicing and encoding different isoforms, have been described. Several of these were isolated by virtue of their binding to either strand of an upstream element of c-myc (MSSPs), or by phenotypic complementation of cdc2 and cdc13 mutants of yeast (scr2), or as a potential human repressor of HIV-1 and ILR-2 alpha promoter transcription (YC1). A pseudogene for this locus is found on chromosome 12.[8]

Interactions

RBMS1 has been shown to interact with Polymerase (DNA directed), alpha 1.[9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000153250 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026970 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Kanaoka Y, Nojima H (August 1994). "SCR: novel human suppressors of cdc2/cdc13 mutants of Schizosaccharomyces pombe harbour motifs for RNA binding proteins". Nucleic Acids Res. 22 (13): 2687–93. doi:10.1093/nar/22.13.2687. PMC 308228. PMID 8041632.
  6. ↑ Negishi Y, Nishita Y, Saëgusa Y, Kakizaki I, Galli I, Kihara F, Tamai K, Miyajima N, Iguchi-Ariga SM, Ariga H (April 1994). "Identification and cDNA cloning of single-stranded DNA binding proteins that interact with the region upstream of the human c-myc gene". Oncogene. 9 (4): 1133–43. PMID 8134115.
  7. ↑ Takai T, Nishita Y, Iguchi-Ariga SM, Ariga H (1994). "Molecular cloning of MSSP-2, a c-myc gene single-strand binding protein: characterization of binding specificity and DNA replication activity". Nucleic Acids Res. 22 (25): 5576–81. doi:10.1093/nar/22.25.5576. PMC 310119. PMID 7838710.
  8. 1 2 "Entrez Gene: RBMS1 RNA binding motif, single stranded interacting protein 1".
  9. ↑ Niki T, Galli I, Ariga H, Iguchi-Ariga SM (June 2000). "MSSP, a protein binding to an origin of replication in the c-myc gene, interacts with a catalytic subunit of DNA polymerase alpha and stimulates its polymerase activity". FEBS Lett. 475 (3): 209–12. doi:10.1016/S0014-5793(00)01679-3. PMID 10869558. S2CID 31594271.

Further reading


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