RDH12
Identifiers
AliasesRDH12, LCA13, LCA3, RP53, SDR7C2, retinol dehydrogenase 12 (all-trans/9-cis/11-cis), retinol dehydrogenase 12
External IDsOMIM: 608830 MGI: 1925224 HomoloGene: 110830 GeneCards: RDH12
Orthologs
SpeciesHumanMouse
Entrez

145226

77974

Ensembl

ENSG00000139988

ENSMUSG00000021123

UniProt

Q96NR8

Q8BYK4

RefSeq (mRNA)

NM_152443

NM_030017
NM_001313971

RefSeq (protein)

NP_689656

NP_001300900
NP_084293

Location (UCSC)Chr 14: 67.7 – 67.73 MbChr 12: 79.26 – 79.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Retinol dehydrogenase 12 is an enzyme that in humans is encoded by the RDH12 gene.[5][6][7]

Retinoids are indispensable light-sensitive elements of vision and also serve as essential modulators of cellular differentiation and proliferation in diverse cell types. RDH12 belongs to a family of dual-specificity retinol dehydrogenases that metabolize both all-trans- and cis-retinols (Haeseleer et al., 2002).[supplied by OMIM][7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000139988 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021123 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Haeseleer F, Jang GF, Imanishi Y, Driessen CA, Matsumura M, Nelson PS, Palczewski K (Nov 2002). "Dual-substrate Specificity Short Chain Retinol Dehydrogenases from the Vertebrate Retina". Journal of Biological Chemistry. 277 (47): 45537–46. doi:10.1074/jbc.M208882200. PMC 1435693. PMID 12226107.
  6. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chemico-Biological Interactions. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
  7. 1 2 "Entrez Gene: RDH12 retinol dehydrogenase 12 (all-trans/9-cis/11-cis)".

Further reading


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