RGS6

RGS6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ES0
Identifiers
Aliases	RGS6, GAP, regulator of G-protein signaling 6, regulator of G protein signaling 6, HA117, S914
External IDs	OMIM: 603894 MGI: 1354730 HomoloGene: 68385 GeneCards: RGS6
Gene location (Human)
Chr.	Chromosome 14 (human)
End	72,566,529 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	83,208,830 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; middle temporal gyrus; ; Achilles tendon; ; prefrontal cortex; ; Brodmann area 23; ; monocyte; ; sperm; ; Brodmann area 9; ; left ventricle; ; cingulate gyrus;
	Top expressed in
	facial motor nucleus; ; superior frontal gyrus; ; cerebellar cortex; ; aortic valve; ; atrium; ; endocardial cushion; ; substantia nigra; ; habenula; ; barrel cortex; ; primary motor cortex;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; GTPase activator activity; GTPase activity;
Cellular component	cytosol; plasma membrane; membrane; nucleus; extrinsic component of membrane; cytoplasm; intracellular anatomical structure;
Biological process	G protein-coupled receptor signaling pathway; positive regulation of GTPase activity; negative regulation of signal transduction; intracellular signal transduction; regulation of G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	9628
	50779
	ENSG00000182732
	ENSMUSG00000021219
	P49758
	Q9Z2H2
NM_001204416; NM_001204417; NM_001204418; NM_001204419; NM_001204420;
	NM_001204421; NM_001204422; NM_001204423; NM_001204424; NM_004296
	NM_001282061; NM_015812; NM_001310478
NP_001191345; NP_001191346; NP_001191347; NP_001191348; NP_001191349;
	NP_001191350; NP_001191351; NP_001191352; NP_001191353; NP_004287; NP_001357199; NP_001357200; NP_001357201; NP_001357202; NP_001357203; NP_001357204; NP_001357205; NP_001357206; NP_001357207; NP_001357208; NP_001357209; NP_001357210; NP_001357211; NP_001357212; NP_001357213; NP_001357215; NP_001357216; NP_001357217; NP_001357218; NP_001357219; NP_001357220; NP_001357221; NP_001357222; NP_001357223
	NP_001268990; NP_001297407; NP_056627
	Wikidata
View/Edit Human	View/Edit Mouse

Regulator of G-protein signaling 6 is a protein that in humans is encoded by the RGS6 gene.^[5]^[6]^[7]

Members of the RGS (regulator of G protein signaling) family have been shown to modulate the functioning of G proteins by activating the intrinsic GTPase activity of the alpha (guanine nucleotide-binding) subunits.[supplied by OMIM]^[7]

Interactions

RGS6 has been shown to interact with STMN2^[8] and DMAP1.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000182732 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021219 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Seki N, Hattori A, Hayashi A, Kozuma S, Hori T, Saito T (April 1999). "The human regulator of G-protein signaling protein 6 gene (RGS6) maps between markers WI-5202 and D14S277 on chromosome 14q24.3". Journal of Human Genetics. 44 (2): 138–40. doi:10.1007/s100380050129. PMID 10083744.
1 2 Liu Z, Fisher RA (April 2004). "RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity". The Journal of Biological Chemistry. 279 (14): 14120–8. doi:10.1074/jbc.M309547200. PMID 14734556.
1 2 "Entrez Gene: RGS6 regulator of G-protein signalling 6".
↑ Liu Z, Chatterjee TK, Fisher RA (October 2002). "RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6". The Journal of Biological Chemistry. 277 (40): 37832–9. doi:10.1074/jbc.M205908200. PMID 12140291.

Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin JF, Bruni AC, Montesi MP, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sanseau P, Polinsky RJ, Wasco W, Da Silva HA, Haines JL, Perkicak-Vance MA, Tanzi RE, Roses AD, Fraser PE, Rommens JM, St George-Hyslop PH (June 1995). "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease". Nature. 375 (6534): 754–60. Bibcode:1995Natur.375..754S. doi:10.1038/375754a0. PMID 7596406. S2CID 4308372.
Snow BE, Betts L, Mangion J, Sondek J, Siderovski DP (May 1999). "Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11". Proceedings of the National Academy of Sciences of the United States of America. 96 (11): 6489–94. Bibcode:1999PNAS...96.6489S. doi:10.1073/pnas.96.11.6489. PMC 26909. PMID 10339615.
Posner BA, Gilman AG, Harris BA (October 1999). "Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways". The Journal of Biological Chemistry. 274 (43): 31087–93. doi:10.1074/jbc.274.43.31087. PMID 10521509.
Liu Z, Chatterjee TK, Fisher RA (October 2002). "RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6". The Journal of Biological Chemistry. 277 (40): 37832–9. doi:10.1074/jbc.M205908200. PMID 12140291.
Chatterjee TK, Fisher RA (August 2003). "Mild heat and proteotoxic stress promote unique subcellular trafficking and nucleolar accumulation of RGS6 and other RGS proteins. Role of the RGS domain in stress-induced trafficking of RGS proteins". The Journal of Biological Chemistry. 278 (32): 30272–82. doi:10.1074/jbc.M212688200. PMID 12761220.
Chatterjee TK, Liu Z, Fisher RA (August 2003). "Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants". The Journal of Biological Chemistry. 278 (32): 30261–71. doi:10.1074/jbc.M212687200. PMID 12761221.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000182732 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021219 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10083744-5] Seki N, Hattori A, Hayashi A, Kozuma S, Hori T, Saito T (April 1999). "The human regulator of G-protein signaling protein 6 gene (RGS6) maps between markers WI-5202 and D14S277 on chromosome 14q24.3". Journal of Human Genetics. 44 (2): 138–40. doi:10.1007/s100380050129. PMID 10083744.

[pmid14734556-6] 1 2 Liu Z, Fisher RA (April 2004). "RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity". The Journal of Biological Chemistry. 279 (14): 14120–8. doi:10.1074/jbc.M309547200. PMID 14734556.

[entrez-7] 1 2 "Entrez Gene: RGS6 regulator of G-protein signalling 6".

[pmid12140291-8] Liu Z, Chatterjee TK, Fisher RA (October 2002). "RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6". The Journal of Biological Chemistry. 277 (40): 37832–9. doi:10.1074/jbc.M205908200. PMID 12140291.

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Interactions

References

Further reading