RRAGC

RRAGC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LLU
Identifiers
Aliases	RRAGC, GTR2, RAGC, TIB929, Ras related GTP binding C
External IDs	OMIM: 608267 MGI: 1858751 HomoloGene: 39141 GeneCards: RRAGC
Gene location (Human)
Chr.	Chromosome 1 (human)
End	38,859,772 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	123,830,790 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; monocyte; ; smooth muscle tissue; ; skin of abdomen; ; gastric mucosa; ; stromal cell of endometrium; ; right coronary artery; ; left coronary artery; ; gallbladder; ; Achilles tendon;
	Top expressed in
	secondary oocyte; ; calvaria; ; brown adipose tissue; ; motor neuron; ; white adipose tissue; ; facial motor nucleus; ; condyle; ; iris; ; conjunctival fornix; ; fossa;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; GTPase activity; magnesium ion binding; GDP binding; protein heterodimerization activity; GTPase binding;
Cellular component	cytoplasm; cytosol; intracellular membrane-bounded organelle; lysosome; nucleus; Gtr1-Gtr2 GTPase complex;
Biological process	regulation of TOR signaling; small GTPase mediated signal transduction; cellular response to amino acid starvation; transcription, DNA-templated; cell growth; RNA splicing; apoptotic process; regulation of TORC1 signaling; response to amino acid; regulation of autophagy; regulation of macroautophagy; positive regulation of TOR signaling; cellular response to amino acid stimulus; cellular response to starvation;
	Sources:Amigo / QuickGO
Orthologs
	64121
	54170
	ENSG00000116954
	ENSMUSG00000028646
	Q9HB90
	Q99K70
	NM_022157; NM_001271851
	NM_017475
	NP_001258780; NP_071440
	NP_059503
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related GTP binding C, also known as RRAGC, is a protein which in humans is encoded by the RRAGC gene.^[5]^[6]

RRAGC is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways.^[5]

Interactions

RRAGC has been shown to interact with RRAGA.^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000116954 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028646 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: RRAGC Ras-related GTP binding C".
1 2 Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (Mar 2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B". The Journal of Biological Chemistry. 276 (10): 7246–57. doi:10.1074/jbc.M004389200. PMID 11073942.
↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Horwitz MS (Jan 2001). "Adenovirus immunoregulatory genes and their cellular targets". Virology. 279 (1): 1–8. doi:10.1006/viro.2000.0738. PMID 11145883.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Sekiguchi T, Todaka Y, Wang Y, Hirose E, Nakashima N, Nishimoto T (Feb 2004). "A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D". The Journal of Biological Chemistry. 279 (9): 8343–50. doi:10.1074/jbc.M305935200. PMID 14660641.
Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (Mar 2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B". The Journal of Biological Chemistry. 276 (10): 7246–57. doi:10.1074/jbc.M004389200. PMID 11073942.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000116954 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028646 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: RRAGC Ras-related GTP binding C".

[pmid11073942-6] 1 2 Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (Mar 2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B". The Journal of Biological Chemistry. 276 (10): 7246–57. doi:10.1074/jbc.M004389200. PMID 11073942.

[pmid16189514-7] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

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Interactions

References

Further reading