Raul Andino
Born1957
AwardsBeijerinck Virology Prize (2017)[1]
Academic background
Academic advisorsDavid Baltimore
Academic work
Doctoral studentsShane Crotty (2001)

Raul Andino is a virologist and professor in the Department of Microbiology and Immunology at the University of California, San Francisco.[2] He is noted for leading a team of researchers that developed the first new oral polio vaccine in 50 years.[3]

Early life and education

Raul Andino was born in 1957[1] in Argentina.[4] He completed his master's degree in Biology in 1980 and his Ph.D. in Chemistry in 1986, both at the University of Buenos Aires.[2]

Andino emigrated to the United States in the 1980s.[4] He then went on to work as a postdoctoral researcher first at the Whitehead Institute for Biomedical Research from 1986 to 1991, then at Rockefeller University in the lab of David Baltimore from 1991 to 1992.[2] He then joined the faculty of the University of California, San Francisco as an assistant professor.[2] He was promoted to associate professor in 1999, then full professor in 2003.[2]

Research

Raul Andino's research has long focused on poliovirus. Together with Andrew Macadam, Andino redesigned the polio vaccine so it can stop the virus from re-evolving.[5][6] His research has expanded to other enteroviruses and host defenses against other RNA viruses.[1] His group has also had a long-standing interest in RNA interference as an antiviral defense, and in the dynamics of viral evolution during infection and transmission.[1]

Notable publications

  • Vignuzzi M, Stone JK... Andino R (2006). Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population. Nature. 439(7074): pgs. 344-348
  • Gitlin L, Karelsky S, Andino R (2002). Short interfering RNA confers intracellular antiviral immunity in human cells. Nature. 418(6896): pgs. 430-434
  • Crotty S, Camerson SE, Andino R (2001). RNA virus error catastrophe: direct molecular test using ribavirin. Proceedings of the National Academy of Sciences of the United States of America. 98(12): pgs. 6895-6900
  • Gamarnik AV, Andino R (1998). Switch from translation to RNA replication in a positive-stranded RNA virus. Genes and Development. 12(15) pgs. 2293-2304
  • Andino R, Rieckhof GE... Baltimore D (1993). Poliovirus RNA synthesis utilizes an RNP complex formed around the 5'-end of the viral RNA. EMBO Journal. 12(9): pgs. 3587-3598

References

  1. 1 2 3 4 "Academy Beijerinck Prize for American Virologyo Raul Andino". Koninkllejke Nederlandse Akademie van Wetenschappen. 27 February 2017. Retrieved 11 July 2019.
  2. 1 2 3 4 5 "Raul Andino, PhD". UCSF. Retrieved 11 July 2019.
  3. ↑ "'Designer Virus' is First New Polio Vaccine in 50 Years". ‘Designer Virus’ is First New Polio Vaccine in 50 Years | UC San Francisco. 23 April 2020. Retrieved 2020-06-23.
  4. 1 2 Christian, Carlos (2020-06-12). "The first polio vaccine in half a century reactivates the hope of eradicating a disease again | Future Planet | The Union Journal". Retrieved 2020-06-23.
  5. ↑ Rees, Victoria (April 28, 2020). "Researchers design first new polio vaccine in 50 years". EPR. Retrieved June 24, 2010.
  6. ↑ Kaltwasser, Jared (May 4, 2020). "New Oral Polio Vaccine Candidate Could Signal Strategy to Fight COVID-19". ContagionLive. Retrieved 2020-06-23.
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