| Renal cell carcinoma with t(6;11) translocation | |
|---|---|
| Specialty | Oncology/nephrology |
Renal cell carcinoma with t(6;11) translocation or TFEB-amplified Renal Cell Carcinomas is rare subtype of renal cell carcinoma. The t(6;11)(p21;q12) translocation fuses the Alpha (MALAT1) gene with the TFEB transcription factor gene, resulting in upregulated expression of TFEB which leads to expression of melanocytic markers.[1]
References
- ↑ Pedram Argani, Victor E. Reuter, Lei Zhang, Yun-Shao Sung, Yi Ning, Jonathan I. Epstein, George J. Netto, and Cristina R. Antonescu: TFEB-amplified Renal Cell Carcinomas: An Aggressive Molecular Subset Demonstrating Variable Melanocytic Marker Expression and Morphologic Heterogeneity. Am J Surg Pathol. 2016 Nov;40(11):1484-1495. PMID 27565001
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