RivX
Predicted secondary structure of RivX sRNA
Identifiers
SymbolRivX
Other data
RNA typesRNA
Domain(s)Streptococcus pyogenes
PDB structuresPDBe

RivX sRNA is a non-coding RNA molecule involved in the interface between two key regulators of virulence in the human pathogen Streptococcus pyogenes (Group A Streptoccus, also known as GAS): the CovR/S system[1] and Mga regulator.[2] This RNA, along with its downstream protein-coding gene RivR, are the first discovered links between these two important regulation networks.[2] An extra protein linking the two pathways, TrxR, was described a year later.[3] The adjoining of these two pathways could allow a consistently high virulence of S. pyogenes despite a variety of environmental conditions.[2]

RivX is thought to be co-transcribed with RivR mRNA before post-transcriptional processing releases the sRNA. It was found to be a non-coding transcript through site-directed mutagenesis experimentation.[2]

In total, the GAS genome is now predicted to encode 75 total sRNAs, a number approximately equal to the number of transcription factors encoded by the genome, which shows the importance of RNA regulation in GAS.[4]

References

  1. ↑ Churchward G (April 2007). "The two faces of Janus: virulence gene regulation by CovR/S in group A streptococci". Molecular Microbiology. 64 (1): 34–41. doi:10.1111/j.1365-2958.2007.05649.x. PMID 17376070.
  2. 1 2 3 4 Roberts SA, Scott JR (December 2007). "RivR and the small RNA RivX: the missing links between the CovR regulatory cascade and the Mga regulon". Molecular Microbiology. 66 (6): 1506–1522. doi:10.1111/j.1365-2958.2007.06015.x. PMID 18005100.
  3. ↑ Leday TV, Gold KM, Kinkel TL, Roberts SA, Scott JR, McIver KS (October 2008). "TrxR, a new CovR-repressed response regulator that activates the Mga virulence regulon in group A Streptococcus". Infection and Immunity. 76 (10): 4659–4668. doi:10.1128/IAI.00597-08. PMC 2546847. PMID 18678666.
  4. ↑ Perez N, Treviño J, Liu Z, Ho SC, Babitzke P, Sumby P (November 2009). "A genome-wide analysis of small regulatory RNAs in the human pathogen group A Streptococcus". PLOS ONE. 4 (11): e7668. Bibcode:2009PLoSO...4.7668P. doi:10.1371/journal.pone.0007668. PMC 2765633. PMID 19888332.
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