Robert M. Graham

AO, FAA, FAHMS
Robert M Graham
Born1948
Sydney, Australia
NationalityAustralian, American
Alma materUniversity of New South Wales
Occupation(s)Cardiologist
Scientist
Known forContributions to adrenergic receptor structure, function and signalling
AwardsForeign Member, Royal Danish Academy of Sciences and Letters (2010)
Scientific career
FieldsMolecular Cardiology
Molecular Pharmacology
InstitutionsVictor Chang Cardiac Research Institute
University of New South Wales
University of Texas Southwestern Medical School
Harvard Medical School
Cleveland Clinic Foundation
ThesisMolecular characterization of the α1-adrenergic receptor (1988)
WebsiteProfessor Bob Graham

Robert Michael Graham AO, FAA, FAHMS (born 1948) is an Australian-born clinician-scientist. He is the Des Renford Professor of Medicine at University of New South Wales[1] and the Head of the Molecular Cardiology and Biophysics Division at Victor Chang Cardiac Research Institute.[2]

Education

Robert Graham received his medical training, MBBS with Honours, and his MD degree from the University of New South Wales. He then trained as a physician in internal medicine and cardiorenal disease in Australia and the US, leading to Fellowships of the Royal Australian College of Physicians and the American College of Physicians.

In the US he received postdoctoral training in pharmacology (Alfred G. Gilman, Chairman and Nobel Laureate) and medicine (Don Seldin, Chairman) at the University of Texas Southwestern Medical School. Graham was then appointed as an Assistant Professor in Pharmacology and Medicine at University of Texas Southwestern Medical School.[3]

Career

In 1982, Graham moved to the Massachusetts General Hospital (Cellular and Molecular Research Laboratory, Edgar Haber, Chairman) and Harvard Medical School, Boston as an Associate Professor of Medicine. During his time in Boston, he did a sabbatical in the laboratory of Nobel Laureate H. Gobind Khorana at the Massachusetts Institute of Technology. In 1989, he moved to the Cleveland Clinic Foundation as the Robert C. Tarazi Chairman of the Molecular Cardiology Department, and Professor of Physiology and Biophysics at Case Western Reserve University School of Medicine, Cleveland, Ohio.[3]

Graham returned to Australia in 1994 as the inaugural Executive Director at the Victor Chang Cardiac Research Institute.[4] He held the position until stepping down in March 2020.[5]

Research

Graham's research is reported in over 290 peer-reviewed papers[6] and cited over 26,000 times.[7]

For many years his research has focused on molecular cardiology, with emphasis on circulatory control mechanisms, receptor signalling, hypertension and cardiac hypertrophy. Together with Charles Homcy, his work contributed to understanding receptor structure, function and signalling. This work subsequently led to the discovery that a protein crosslinking enzyme also functions as a unique multifunctional protein involved in receptor signalling.[8][9]

More recently, together with colleagues, Ahsan Husain and Siiri Iismaa, Graham has been actively involved in studies of cardiac regeneration and the application of stem cells for the treatment of heart diseases, and with A/Prof Eleni Giannoulatou, the pathophysiology and genetics of spontaneous coronary artery dissection.[10]

In 2021, with Glenn King and Nathan Palpant, he co-founded Infensa Bioscience, an Australian biotechnology company.[11]

He serves on the Board of Directors of the Lowy Medical Research Institute[12][13] in California; and Impedimed,[14][15] a Brisbane-based medical device company.

Awards and recognition

References

  1. ↑ "The heart that regenerates itself". UNSW Medicine - St Vincent's Clinical School.
  2. ↑ "Molecular Cardiology Laboratory - Victor Chang Institute". The Victor Chang Cardiac Research Institute. Retrieved 2021-09-09.
  3. 1 2 "Professor Bob Graham | Victor Chang Cardiac Research Institute". The Victor Chang Cardiac Research Institute. Retrieved 2021-09-09.
  4. ↑ "How billionaires, surgeons and royals built the Victor Chang institute". Australian Financial Review. 2019-11-15. Retrieved 2021-09-09.
  5. ↑ Professor Bob Graham steps down after 25 years at Victor Chang Cardiac Research Institute, Australian Broadcasting Corporation, 2019-11-19, retrieved 2021-09-09
  6. ↑ "Select Publications by Professor Robert M Graham". UNSW Sydney.
  7. ↑ "Robert M Graham". Google Scholar.
  8. ↑ Nakaoka, H.; Perez, D. M.; Baek, K. J.; Das, T.; Husain, A.; Misono, K.; Im, M. J.; Graham, R. M. (1994-06-10). "Gh: a GTP-binding protein with transglutaminase activity and receptor signaling function". Science. 264 (5165): 1593–1596. doi:10.1126/science.7911253. ISSN 0036-8075. PMID 7911253.
  9. ↑ Lorand, Laszlo; Graham, Robert M. (February 2003). "Transglutaminases: crosslinking enzymes with pleiotropic functions". Nature Reviews. Molecular Cell Biology. 4 (2): 140–156. doi:10.1038/nrm1014. ISSN 1471-0072. PMID 12563291. S2CID 19353789.
  10. ↑ Iismaa, Siiri E.; Hesselson, Stephanie; McGrath-Cadell, Lucy; Muller, David W.; Fatkin, Diane; Giannoulatou, Eleni; Kovacic, Jason; Graham, Robert M. (2021-01-01). "Spontaneous Coronary Artery Dissection and Fibromuscular Dysplasia: Vasculopathies With a Predilection for Women". Heart, Lung and Circulation. 30 (1): 27–35. doi:10.1016/j.hlc.2020.05.110. ISSN 1443-9506. PMC 7710561. PMID 32713767.
  11. ↑ "Infensabioscience Pty Ltd - ASIC - Company Dataset | Australia Datasets 💿". aus.databasesets.com. Retrieved 2021-11-03.
  12. ↑ "Lowy Medical Research Institute Limited" (PDF). Treasury.
  13. ↑ "Robert Graham, AO, FAA, MD". The Lowy Medical Research Institute. 2015-11-24. Retrieved 2021-09-09.
  14. ↑ "ImpediMed announces changes to Board of Directors".
  15. ↑ "Robert M. Graham, AO, FAA, FAHMS, MBBS, MD, FRACP, FACP, FAHA | ImpediMed". www.impedimed.com. Retrieved 2021-09-09.
  16. ↑ "R T Hall Prize Recipients" (PDF). Cardiac Society of Australia and New Zealand. Retrieved 10 January 2022.
  17. ↑ "Centenary Medals for 15,464". The Sydney Morning Herald. 2003-04-25. Retrieved 2021-09-09.
  18. ↑ "AUSTRALIAN HONOURS SEARCH FACILITY". honours.pmc.gov.au. Retrieved 2021-09-09.
  19. ↑ "Campaign to merge MRIs under fire". AAMRI. 2009-12-02. Retrieved 2021-09-09.
  20. ↑ "Royal Academy". www.royalacademy.dk. Retrieved 2021-09-09.
  21. ↑ "Annual Report 2016" (PDF). The Heart Foundation - New South Wales.
  22. ↑ "Fellowship of the Australian Academy of Health and Medical Sciences October 2016" (PDF). Fellowship of the Australian Academy of Health and Medical Sciences.
  23. ↑ "Directors & Executive | Australian Cardiovascular Alliance (ACvA) - Australian Cardiovascular Alliance (ACvA)". Retrieved 2021-09-09.
  24. ↑ "Annual Review 2016" (PDF). Heart Foundation.
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