SdsR/RyeB RNA
Predicted secondary structure and sequence conservation of SdsR_RyeB
Identifiers
SymbolSdsR_RyeB
RfamRF00111
Other data
RNA typeGene; sRNA
Domain(s)Bacteria
SOSO:0000655
PDB structuresPDBe

The SdsR/RyeB RNA is a non-coding RNA that was identified in a large scale screen of E. coli.[1] The exact 5′ and 3′ ends of this RNA are uncertain. This RNA overlaps the SraC/RyeA RNA on the opposite strand suggesting that the two may act in a concerted manner. It is transcribed by general stress factor σs and is most highly expressed in stationary phase. SdsR/RyeB RNA interacts with Hfq.

The homologous sRNA in S. enterica was shown to regulate synthesis of major porin OmpD.[2] A study using Salmonella identified 20 targets of this sRNA including transcriptional regulator, CRP, global DNA-binding factors, StpA and HupB, the antibiotic transporter protein, TolC, and the RtsA/B two-component system (TCS), and validated their post-transcriptional control by SdsR/RyeB RNA.[3]

See also

References

  1. ↑ Wassarman KM, Repoila F, Rosenow C, Storz G, Gottesman S (July 2001). "Identification of novel small RNAs using comparative genomics and microarrays". Genes & Development. 15 (13): 1637–1651. doi:10.1101/gad.901001. PMC 312727. PMID 11445539.
  2. ↑ Fröhlich KS, Papenfort K, Berger AA, Vogel J (April 2012). "A conserved RpoS-dependent small RNA controls the synthesis of major porin OmpD". Nucleic Acids Research. 40 (8): 3623–3640. doi:10.1093/nar/gkr1156. PMC 3333887. PMID 22180532.
  3. ↑ Fröhlich KS, Haneke K, Papenfort K, Vogel J (December 2016). "The target spectrum of SdsR small RNA in Salmonella". Nucleic Acids Research. 44 (21): 10406–10422. doi:10.1093/nar/gkw632. PMC 5137417. PMID 27407104.
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