S8, S-8, or S 8 may refer to:
Transportation
- S8 (Berlin), a S-Bahn line in Berlin, Germany
- S8 (Milan suburban railway network)
- S8 (Munich)
- Expressway S8 (Poland)
- S8 (RER Vaud)
- S8 (Rhine-Main S-Bahn)
- S8 (Rhine-Ruhr S-Bahn) in North Rhine-Westphalia, Germany
- S8 (ZVV), a S-Bahn line in the cantons of Zürich and Zug in Switzerland
- Short S.8 Calcutta, British transport flying boat
- Stagecoach Gold bus route S8, a bus route in Oxfordshire, England
- S8, a line in the Brussels Regional Express Network
- Line S8 (Nanjing Metro)
- London Underground S8 Stock
Other uses
- S8 (classification), for disabled swimmers
- S-8 (rocket), a Russian air-to-surface missile
- S8: Keep container dry, a safety phrase in chemistry
- Samsung Galaxy S8, a smartphone by Samsung
- Samsung Galaxy Tab S8, a tablet computer by Samsung
- Octasulfur, the main allotrope of sulfur, having the formula S8
- Audi S8, German car
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