SCG2
Identifiers
AliasesSCG2, CHGC, SN, SgII, secretogranin II
External IDsOMIM: 118930 MGI: 103033 HomoloGene: 2591 GeneCards: SCG2
Orthologs
SpeciesHumanMouse
Entrez

7857

20254

Ensembl

ENSG00000171951

ENSMUSG00000050711

UniProt

P13521
P15321

Q03517

RefSeq (mRNA)

NM_003469

NM_009129
NM_001310680

RefSeq (protein)

NP_003460

NP_001297609
NP_033155

Location (UCSC)Chr 2: 223.6 – 223.6 MbChr 1: 79.41 – 79.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SCG2, also called secretogranin II (chromogranin C), is a protein which in humans is encoded by the SCG2 gene.[5]

Function

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotactic effects on specific cell types, and EM66, whose function is unknown.[6]

See also

Further reading

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000171951 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050711 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Gerdes HH, Rosa P, Phillips E, Baeuerle PA, Frank R, Argos P, Huttner WB (July 1989). "The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH- and calcium-induced aggregation". J. Biol. Chem. 264 (20): 12009–15. doi:10.1016/S0021-9258(18)80167-3. PMID 2745426.
  6. "Entrez Gene: SCG2".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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