SCGB1D2
Identifiers
AliasesSCGB1D2, LIPB, LPHB, LPNB, secretoglobin, family 1D member 2, secretoglobin family 1D member 2
External IDsOMIM: 615061 HomoloGene: 88740 GeneCards: SCGB1D2
Orthologs
SpeciesHumanMouse
Entrez

10647

n/a

Ensembl

ENSG00000124935

n/a

UniProt

O95969

n/a

RefSeq (mRNA)

NM_006551

n/a

RefSeq (protein)

NP_006542

n/a

Location (UCSC)Chr 11: 62.24 – 62.24 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Secretoglobin family 1D member 2 is a protein that in humans is encoded by the SCGB1D2 gene.[3][4][5]

Function

The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. Lipophilin gene products are widely expressed in normal tissues, especially in endocrine-responsive organs. Assuming that human lipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroid hormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 10, this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2.[5]

SCGB1D2 expression is high in mammary tissue, and is sometimes used for identification and detection of disseminated breast cancer cells.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000124935 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑ Zhao C, Nguyen T, Yusifov T, Glasgow BJ, Lehrer RI (March 1999). "Lipophilins: human peptides homologous to rat prostatein". Biochemical and Biophysical Research Communications. 256 (1): 147–55. doi:10.1006/bbrc.1999.0274. PMID 10066439.
  4. ↑ Lehrer RI, Xu G, Abduragimov A, Dinh NN, Qu XD, Martin D, Glasgow BJ (August 1998). "Lipophilin, a novel heterodimeric protein of human tears". FEBS Letters. 432 (3): 163–7. doi:10.1016/S0014-5793(98)00852-7. PMID 9720917. S2CID 205880914.
  5. 1 2 "Entrez Gene: SCGB1D2 secretoglobin, family 1D, member 2".
  6. ↑ Lacroix M (December 2006). "Significance, detection and markers of disseminated breast cancer cells". Endocrine-Related Cancer. Bioscientifica. 13 (4): 1033–67. doi:10.1677/ERC-06-0001. PMID 17158753.

Further reading

  • Culleton J, O'Brien N, Ryan BM, Hill AD, McDermott E, O'Higgins N, Duffy MJ (March 2007). "Lipophilin B: A gene preferentially expressed in breast tissue and upregulated in breast cancer". International Journal of Cancer. 120 (5): 1087–92. doi:10.1002/ijc.22471. PMID 17163411. S2CID 20729571.
  • Sjödin A, Guo D, Lund-Johansen M, Krossnes BK, Lilleng P, Henriksson R, Hedman H (April 2005). "Secretoglobins in the human pituitary: high expression of lipophilin B and its down-regulation in pituitary adenomas". Acta Neuropathologica. 109 (4): 381–6. doi:10.1007/s00401-004-0972-6. PMID 15668787. S2CID 20395605.
  • Carter D, Dillon DC, Reynolds LD, Retter MW, Fanger G, Molesh DA, Sleath PR, McNeill PD, Vedvick TS, Reed SG, Persing DH, Houghton RL (February 2003). "Serum antibodies to lipophilin B detected in late stage breast cancer patients". Clinical Cancer Research. 9 (2): 749–54. PMID 12576445.
  • Carter D, Douglass JF, Cornellison CD, Retter MW, Johnson JC, Bennington AA, Fleming TP, Reed SG, Houghton RL, Diamond DL, Vedvick TS (May 2002). "Purification and characterization of the mammaglobin/lipophilin B complex, a promising diagnostic marker for breast cancer". Biochemistry. 41 (21): 6714–22. doi:10.1021/bi0159884. PMID 12022875.
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