| SFXN1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | SFXN1, TCC, sideroflexin 1, SLC56A1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 615569 MGI: 2137677 HomoloGene: 41494 GeneCards: SFXN1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Sideroflexin-1 is a protein that in humans is encoded by the SFXN1 gene.[5] According to Nora Kory et al., SFXN1 gene product has mitochondrial serine transporter activity.[6]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000164466 - Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021474 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Entrez Gene: SFXN1 sideroflexin 1".
- ↑ Kory N, Wyant GA, Prakash G, Uit de Bos J, Bottanelli F, Pacold ME, et al. (November 2018). "SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism". Science. 362 (6416): eaat9528. doi:10.1126/science.aat9528. PMC 6300058. PMID 30442778.
Further reading
- Kaplan RS, Mayor JA (October 1993). "Structure, function and regulation of the tricarboxylate transport protein from rat liver mitochondria". Journal of Bioenergetics and Biomembranes. 25 (5): 503–14. doi:10.1007/BF01108407. PMID 8132490. S2CID 24848406.
- Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, et al. (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Fleming MD, Campagna DR, Haslett JN, Trenor CC, Andrews NC (March 2001). "A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice". Genes & Development. 15 (6): 652–7. doi:10.1101/gad.873001. PMC 312659. PMID 11274051.
- Zara V, Giudetti AM, Siculella L, Palmieri F, Gnoni GV (November 2001). "Covariance of tricarboxylate carrier activity and lipogenesis in liver of polyunsaturated fatty acid (n-6) fed rats". European Journal of Biochemistry. 268 (22): 5734–9. doi:10.1046/j.0014-2956.2001.02508.x. PMID 11722557.
- Miyake S, Yamashita T, Taniguchi M, Tamatani M, Sato K, Tohyama M (July 2002). "Identification and characterization of a novel mitochondrial tricarboxylate carrier". Biochemical and Biophysical Research Communications. 295 (2): 463–8. doi:10.1016/S0006-291X(02)00694-0. PMID 12150972.
- Giudetti AM, Sabetta S, di Summa R, Leo M, Damiano F, Siculella L, Gnoni GV (November 2003). "Differential effects of coconut oil- and fish oil-enriched diets on tricarboxylate carrier in rat liver mitochondria". Journal of Lipid Research. 44 (11): 2135–41. doi:10.1194/jlr.M300237-JLR200. PMID 14634051.
- Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, et al. (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
- Siculella L, Damiano F, Sabetta S, Gnoni GV (July 2004). "n-6 PUFAs downregulate expression of the tricarboxylate carrier in rat liver by transcriptional and posttranscriptional mechanisms". Journal of Lipid Research. 45 (7): 1333–40. doi:10.1194/jlr.M400061-JLR200. PMID 15060089.
- Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Siculella L, Sabetta S, Damiano F, Giudetti AM, Gnoni GV (December 2004). "Different dietary fatty acids have dissimilar effects on activity and gene expression of mitochondrial tricarboxylate carrier in rat liver". FEBS Letters. 578 (3): 280–4. doi:10.1016/j.febslet.2004.11.014. PMID 15589833. S2CID 24071277.
- Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, et al. (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
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