SHPRH

SHPRH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2M85, 4QN1
Identifiers
Aliases	SHPRH, bA545I5.2, SNF2 histone linker PHD RING helicase, RAD5
External IDs	OMIM: 608048 MGI: 1917581 HomoloGene: 6489 GeneCards: SHPRH
Gene location (Human)
Chr.	Chromosome 6 (human)
End	145,964,423 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	11,093,339 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; pancreatic epithelial cell; ; sural nerve; ; retinal pigment epithelium; ; germinal epithelium; ; tibia; ; bone marrow cells; ; seminal vesicula; ; parietal pleura; ; jejunal mucosa;
	Top expressed in
	secondary oocyte; ; cerebellar vermis; ; ganglionic eminence; ; trigeminal ganglion; ; superior cervical ganglion; ; vas deferens; ; medial ganglionic eminence; ; sciatic nerve; ; carotid body; ; atrioventricular valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; nucleotide binding; protein binding; hydrolase activity; ATP binding; helicase activity; metal ion binding; ubiquitin-protein transferase activity; ubiquitin protein ligase binding; transferase activity; ubiquitin protein ligase activity;
Cellular component	nucleosome; nucleus; nucleoplasm;
Biological process	nucleosome assembly; protein polyubiquitination; DNA repair; cellular response to DNA damage stimulus; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	257218
	268281
	ENSG00000146414
	ENSMUSG00000090112
	Q149N8
	Q7TPQ3
	NM_001042683; NM_173082; NM_001370327; NM_001370328
	NM_001077707; NM_001284354; NM_172937
	NP_001036148; NP_775105; NP_001357256; NP_001357257
	NP_001071175; NP_001271283; NP_766525
	Wikidata
View/Edit Human	View/Edit Mouse

E3 ubiquitin-protein ligase SHPRH is an enzyme that in humans is encoded by the SHPRH gene.^[5]^[6]

Function

SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases.[supplied by OMIM]^[6] SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000146414 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000090112 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sood R, Makalowska I, Galdzicki M, Hu P, Eddings E, Robbins CM, Moses T, Namkoong J, Chen S, Trent JM (August 2003). "Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region". Genomics. 82 (2): 153–61. doi:10.1016/S0888-7543(03)00121-6. PMID 12837266.
1 2 "Entrez Gene: SHPRH SNF2 histone linker PHD RING helicase".
↑ Brühl, J; Trautwein, J; Schäfer, A; Linne, U; Bouazoune, K (21 August 2019). "The DNA repair protein SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase". Epigenetics & Chromatin. 12 (1): 52. doi:10.1186/s13072-019-0294-5. PMC 6702750. PMID 31434570.

Motegi A, Sood R, Moinova H, Markowitz SD, Liu PP, Myung K (December 2006). "Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination". The Journal of Cell Biology. 175 (5): 703–8. doi:10.1083/jcb.200606145. PMC 2064669. PMID 17130289.
Unk I, Hajdú I, Fátyol K, Szakál B, Blastyák A, Bermudez V, Hurwitz J, Prakash L, Prakash S, Haracska L (November 2006). "Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen". Proceedings of the National Academy of Sciences of the United States of America. 103 (48): 18107–12. Bibcode:2006PNAS..10318107U. doi:10.1073/pnas.0608595103. PMC 1838714. PMID 17108083.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (August 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization" (PDF). Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000146414 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000090112 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12837266-5] Sood R, Makalowska I, Galdzicki M, Hu P, Eddings E, Robbins CM, Moses T, Namkoong J, Chen S, Trent JM (August 2003). "Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region". Genomics. 82 (2): 153–61. doi:10.1016/S0888-7543(03)00121-6. PMID 12837266.

[entrez-6] 1 2 "Entrez Gene: SHPRH SNF2 histone linker PHD RING helicase".

[7] Brühl, J; Trautwein, J; Schäfer, A; Linne, U; Bouazoune, K (21 August 2019). "The DNA repair protein SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase". Epigenetics & Chromatin. 12 (1): 52. doi:10.1186/s13072-019-0294-5. PMC 6702750. PMID 31434570.

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[3]

[4]

[5]

[6]

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Function

References

Further reading