SIPA1L1

SIPA1L1
Identifiers
Aliases	SIPA1L1, E6TP1, signal induced proliferation associated 1 like 1, SPAR1
External IDs	OMIM: 617504 MGI: 2443679 HomoloGene: 9189 GeneCards: SIPA1L1
Gene location (Human)
Chr.	Chromosome 14 (human)
End	71,741,229 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	82,498,560 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; external globus pallidus; ; caudate nucleus; ; Region I of hippocampus proper; ; sural nerve; ; popliteal artery; ; putamen; ; Brodmann area 46; ; Brodmann area 9; ; Brodmann area 10;
	Top expressed in
	olfactory tubercle; ; temporal lobe; ; nucleus accumbens; ; primary motor cortex; ; prefrontal cortex; ; amygdala; ; Region I of hippocampus proper; ; piriform cortex; ; cingulate gyrus; ; subiculum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity; ephrin receptor binding; molecular function;
Cellular component	cytoplasm; postsynaptic membrane; membrane; postsynaptic density; plasma membrane; dendritic spine; synapse; cell junction; neuron projection; cytoskeleton; cellular component;
Biological process	actin cytoskeleton reorganization; activation of GTPase activity; regulation of GTPase activity; ephrin receptor signaling pathway; regulation of synaptic plasticity; regulation of dendrite morphogenesis; regulation of axonogenesis; regulation of small GTPase mediated signal transduction; regulation of dendritic spine morphogenesis; biological process;
	Sources:Amigo / QuickGO
Orthologs
	26037
	217692
	ENSG00000197555
	ENSMUSG00000042700
	O43166
	Q8C0T5
NM_001284245; NM_001284246; NM_001284247; NM_015556; NM_001354285;
	NM_001354286; NM_001354287; NM_001354288; NM_001354289; NM_001386936
	NM_001167983; NM_172579
NP_001271174; NP_001271175; NP_001271176; NP_056371; NP_001341214;
	NP_001341215; NP_001341216; NP_001341217; NP_001341218
NP_001161455; NP_766167; NP_001394331; NP_001394332; NP_001394333;
	NP_001394334; NP_001394335; NP_001394336; NP_001394337; NP_001394338; NP_001394339; NP_001394340; NP_001394341; NP_001394342; NP_001394343; NP_001394344
	Wikidata
View/Edit Human	View/Edit Mouse

Signal-induced proliferation-associated 1-like protein 1 is a protein that in humans is encoded by the SIPA1L1 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000197555 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042700 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gao Q, Srinivasan S, Boyer SN, Wazer DE, Band V (January 1999). "The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation". Molecular and Cellular Biology. 19 (1): 733–44. doi:10.1128/mcb.19.1.733. PMC 83930. PMID 9858596.
↑ "Entrez Gene: SIPA1L1 signal-induced proliferation-associated 1 like 1".

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX 10.1.1.500.923. doi:10.1093/dnares/9.3.99. PMID 12168954.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Lee C, Wooldridge TR, Laimins LA (February 2007). "Analysis of the roles of E6 binding to E6TP1 and nuclear localization in the human papillomavirus type 31 life cycle". Virology. 358 (1): 201–10. doi:10.1016/j.virol.2006.08.028. PMID 16999984.
Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (June 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Chih DY, Park DJ, Gross M, Idos G, Vuong PT, Hirama T, Chumakov AM, Said J, Koeffler HP (December 2004). "Protein partners of C/EBPepsilon". Experimental Hematology. 32 (12): 1173–81. doi:10.1016/j.exphem.2004.08.014. PMID 15588942.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Nakayama M, Kikuno R, Ohara O (November 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Pak DT, Yang S, Rudolph-Correia S, Kim E, Sheng M (August 2001). "Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP". Neuron. 31 (2): 289–303. doi:10.1016/S0896-6273(01)00355-5. PMID 11502259.
Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1997). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000197555 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042700 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9858596-5] Gao Q, Srinivasan S, Boyer SN, Wazer DE, Band V (January 1999). "The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation". Molecular and Cellular Biology. 19 (1): 733–44. doi:10.1128/mcb.19.1.733. PMC 83930. PMID 9858596.

[entrez-6] "Entrez Gene: SIPA1L1 signal-induced proliferation-associated 1 like 1".

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References

Further reading