SPOCK1
Identifiers
AliasesSPOCK1, SPOCK, TESTICAN, TIC1, sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1, SPARC/osteonectin, cwcv and kazal like domains proteoglycan 1, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1
External IDsOMIM: 602264 MGI: 105371 HomoloGene: 80193 GeneCards: SPOCK1
Orthologs
SpeciesHumanMouse
Entrez

6695

20745

Ensembl

ENSG00000152377

ENSMUSG00000056222

UniProt

Q08629

Q62288

RefSeq (mRNA)

NM_004598

NM_001166463
NM_001166464
NM_001166465
NM_001166466
NM_009262

RefSeq (protein)

NP_004589

n/a

Location (UCSC)Chr 5: 136.98 – 137.6 MbChr 13: 57.57 – 58.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Testican-1 is a protein that in humans is encoded by the SPOCK1 gene.[5][6]

This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is under research, though it is from the same family of glycoproteins as SPARC. It is thought its similarity to thyropin-type cysteine protease inhibitors suggests its function may be related to protease inhibition.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000152377 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056222 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Charbonnier F, Perin JP, Mattei MG, Camuzat A, Bonnet F, Gressin L, Alliel PM (Jun 1998). "Genomic organization of the human SPOCK gene and its chromosomal localization to 5q31". Genomics. 48 (3): 377–80. doi:10.1006/geno.1997.5199. PMID 9545645.
  6. 1 2 "Entrez Gene: SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1".

Further reading


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