ST5
Identifiers
AliasesST5, DENND2B, HTS1, p126, suppression of tumorigenicity 5
External IDsOMIM: 140750 MGI: 108517 HomoloGene: 3951 GeneCards: ST5
Orthologs
SpeciesHumanMouse
Entrez

6764

76954

Ensembl

ENSG00000166444

ENSMUSG00000031024

UniProt

P78524

Q924W7

RefSeq (mRNA)

NM_005418
NM_139157
NM_213618

NM_001001326
NM_029811

RefSeq (protein)

NP_001001326
NP_084087

Location (UCSC)Chr 11: 8.69 – 8.91 MbChr 7: 109.52 – 109.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Suppression of tumorigenicity 5 is a protein that in humans is encoded by the ST5 gene.[5][6] ST5 orthologs[7] have been identified in nearly all mammals for which complete genome data are available.

Function

This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000166444 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031024 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lichy JH, Modi WS, Seuanez HN, Howley PM (August 1992). "Identification of a human chromosome 11 gene which is differentially regulated in tumorigenic and nontumorigenic somatic cell hybrids of HeLa cells". Cell Growth & Differentiation. 3 (8): 541–8. PMID 1390339.
  6. 1 2 "Entrez Gene: ST5 suppression of tumorigenicity 5".
  7. "OrthoMaM phylogenetic marker: ST5 coding sequence".

Further reading


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