| STK17A | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | STK17A, DRAK1, serine/threonine kinase 17a | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 604726 HomoloGene: 55846 GeneCards: STK17A | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Serine/threonine kinase 17a is a protein that in humans is encoded by the STK17A gene.[3]
Function
This gene is a member of the death-associated protein (DAP) kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity.[3]
In a recent study the gene (among others) shows a major role in centenarians longer lifespan.[4]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000164543 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- 1 2 "Entrez Gene: Serine/threonine kinase 17a".
- ↑ Garagnani P, Marquis J, Delledonne M, Pirazzini C, Marasco E, Kwiatkowska KM, et al. (May 2021). Tyler JK, Suh Y, Shuldiner AR (eds.). "Whole-genome sequencing analysis of semi-supercentenarians". eLife. 10: e57849. doi:10.7554/eLife.57849. PMC 8096429. PMID 33941312.
Further reading
- Landa I, Ruiz-Llorente S, Montero-Conde C, Inglada-Pérez L, Schiavi F, Leskelä S, et al. (September 2009). "The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors". PLOS Genetics. 5 (9): e1000637. doi:10.1371/journal.pgen.1000637. PMC 2727793. PMID 19730683.
- Sanjo H, Kawai T, Akira S (October 1998). "DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis". The Journal of Biological Chemistry. 273 (44): 29066–71. doi:10.1074/jbc.273.44.29066. PMID 9786912.
- Mao P, Hever MP, Niemaszyk LM, Haghkerdar JM, Yanco EG, Desai D, et al. (June 2011). "Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells". The Journal of Biological Chemistry. 286 (22): 19381–91. doi:10.1074/jbc.M111.218040. PMC 3103316. PMID 21489989.
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