The Sepsis Six is the name given to a bundle of medical therapies designed to reduce mortality in patients with sepsis.

Drawn from international guidelines that emerged from the Surviving Sepsis Campaign[1][2] the Sepsis Six was developed by The UK Sepsis Trust.[3] (Daniels, Nutbeam, Laver) in 2006 as a practical tool to help healthcare professionals deliver the basics of care rapidly and reliably.

In 2011, The UK Sepsis Trust published evidence that use of the Sepsis Six was associated with a 50% reduction in mortality, a decreased length of stay in hospital, and fewer intensive care days.[4] Though the authors urge caution in a causal interpretation of these findings.

The Sepsis Six consists of three diagnostic and three therapeutic steps – all to be delivered within one hour of the initial diagnosis of sepsis:

  1. Titrate oxygen to a saturation target of 94%
  2. Take blood cultures and consider source control
  3. Administer empiric intravenous antibiotics
  4. Measure serial serum lactates
  5. Start intravenous fluid resuscitation
  6. Commence accurate urine output measurement.

References

  1. ↑ R. Phillip, Dellinger; Mitchell M., Levy; Jean M., Carlet; Julian, Bion; Margaret M., Parker; Roman, Jaeschke; Konrad, Reinhart; Derek C., Angus; Christian, Brun-Buisson; Richard, Beale; et al. (1 January 2008). Buchanan, Timothy G.; Tosta, Sophie M.; Retford, Lynn; Goldberg, Jill; Less, Sarah; Drake, Madison; Maslove, David M.; Deutschmann, Clifford S.; Prough, Donald S. (eds.). "Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008". Critical Care Medicine. Society of Critical Care Medicine/Lippincott Williams & Wilkins. 36 (1): 296–327. doi:10.1097/01.ccm.0000298158.12101.41. ISSN 0090-3493. LCCN 73647665. OCLC 772657699. PMID 18158437. S2CID 220581728. Archived from the original on 16 June 2020 – via PubMed.
  2. ↑ Rhodes, Andrew; Evans, Laura E.; Alhazzani, Waleed; Levy, Mitchell M.; Antonelli, Massimo; Ferrer, Ricard; Kumar, Anand; Sevransky, Jonathan E.; Sprung, Charles L.; Nunnally, Mark E.; et al. (1 March 2017). Buchanan, Timothy G.; Tosta, Sophie M.; Retford, Lynn; Goldberg, Jill; Less, Sarah; Drake, Madison; Maslove, David M.; Deutschmann, Clifford S.; Prough, Donald S. (eds.). "Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016". Critical Care Medicine. Society of Critical Care Medicine/Lippincott Williams & Wilkins. 45 (3): 486–452. doi:10.1097/CCM.0000000000002255. ISSN 0090-3493. LCCN 73647665. OCLC 772657699. PMID 28098591. S2CID 52827184. Archived from the original on 1 February 2020. Retrieved 22 June 2021.
  3. ↑ "Home « The UK Sepsis Trust The UK Sepsis Trust". sepsistrust.org. Retrieved 2014-04-22.
  4. ↑ Daniels, Ron; Nutbeam, Tim; McNamara, Georgina; Galvin, Clare (2011). Godlee, Fiona; Abbasi, Kamran; Bloom, Theodora; Loder, Elizabeth; Coombes, Rebecca; Dobson, Juliet; Kmietowicz, Zosia; Simpson, Paul; Tonks, Alison; Moberly, Tom; et al. (eds.). "The sepsis six and the severe sepsis resuscitation bundle: a prospective observational cohort study". Emergency Medicine Journal. London, England, United Kingdom of Great Britain: BMJ Publishing Group Ltd/British Medical Association. 28 (6): 507–512. doi:10.1136/emj.2010.095067. ISSN 1472-0213. JSTOR 09598138. LCCN 97640199. OCLC 32595642. PMID 21036796. S2CID 26693613. Archived from the original on 2 June 2018.
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