Sergei Mirkin
BornSeptember 29, 1956
Moscow, Russia
Alma materMoscow State University, Russian Academy of Sciences
Known forGenome instability
Scientific career
FieldsBiology, genomics
InstitutionsTufts University

Sergei Mirkin (born September 29, 1956) is a Russian-American biologist who studies genome instability mediated by repetitive DNA during DNA replication and transcription.[1] He is a professor of Genetics and Molecular Biology and holds the White Family Chair in Biology at Tufts University.[2]

Early life and education

Mirkin was born in Moscow, Russia. He attended Moscow State University, where he earned both a Bachelor of Science and a Master of Science degree in Genetics in 1978.[2] Mirkin went on to pursue a PhD in Molecular Biology at the Russian Academy of Sciences’ Institute of Molecular Genetics.[3] His PhD was under the supervision of Roman B. Khesin, a molecular biologist and Mirkin later described his formative years in the Khesin lab in his essay, “Thinking of R.B. Khesin”.[4] By studying conditionally lethal mutants of  DNA gyrase, he established a fundamental interplay between DNA supercoiling and transcription in E. coli.[5]

Career and research

Mirkin conducted his postdoctoral studies at the Institute of Molecular Genetics with Maxim Frank-Kamenetskii, a biophysicist. This work culminated with the discovery of the three-stranded H-DNA structure.[6] Mirkin moved to the US as a Fogarty International Fellow in 1989 and joined the faculty of the Department of Genetics at University of Illinois Chicago (UIC) in 1990.[7] He worked at UIC until 2006 rising to the rank of Professor of Biochemistry and Molecular Genetics. In 2007, he joined Tufts University as a professor and the White Family Chair in Biology.[2]

Mirkin’s major contributions to science include discovering of the first multi-stranded DNA structure (H-DNA);[6] detection of dynamic non-B DNA structures, including DNA cruciforms and triplexes in vivo;[8] establishing that structure-prone DNA repeats stall DNA replication driving their expansions that are responsible for numerous hereditary diseases in humans;[9] and unraveling the mechanisms and consequences of transcription-replication collisions in vivo.[10]

The Mirkin lab continues studying genome structure and function from two perspectives: the mechanisms responsible for the instability of DNA repeats implicated in human disease, the role of transcription-replication collisions in genome instability and the mechanisms of genome instability mediated at interstitial telomeric sequences.[1]

Selected publications

Awards and honors

  • Editor-in-Chief, Current Opinions in Genetics and Development, 2010-2013[2]
  • Distinguished Senior Scholar Award, Tufts University, 2020[11]

References

  1. 1 2 "Mirkin Lab | Department of Biology". as.tufts.edu. Retrieved 2022-11-08.
  2. 1 2 3 4 "Sergei Mirkin | Department of Biology". as.tufts.edu. Retrieved 2022-11-08.
  3. ↑ "Sergei Mirkin – Bio". facultyprofiles.tufts.edu. Retrieved 2022-11-08.
  4. ↑ Mirkin, S. M. (2002). "Thinking of R.B. Khesin". Molecular Biology. 36 (2): 267–279. doi:10.1023/A:1015334325856. S2CID 1820228. ProQuest 760104752.
  5. ↑ Krasilnikov, Andrey S.; Podtelezhnikov, Alexei; Vologodskii, Alexander; Mirkin, Sergei M. (October 1999). "Large-scale effects of transcriptional DNA supercoiling in Vivo 1 1Edited by I. Tinoco". Journal of Molecular Biology. 292 (5): 1149–1160. doi:10.1006/jmbi.1999.3117. PMID 10512709.
  6. 1 2 Frank-Kamenetskii, M. D.; Mirkin, S. M. (1995). "Triplex DNA structures". Annual Review of Biochemistry. 64: 65–95. doi:10.1146/annurev.bi.64.070195.000433. PMID 7574496.
  7. ↑ "ORCID". orcid.org. Retrieved 2022-11-08.
  8. ↑ Dayn, Andrey; Malkhosyan, Sergei; Mirkin, Sergei M. (1992). "Transcriptionally driven cruciform formation in vivo". Nucleic Acids Research. 20 (22): 5991–5997. doi:10.1093/nar/20.22.5991. PMC 334465. PMID 1461732.
  9. ↑ Voineagu, Irina; Surka, Christine F.; Shishkin, Alexander A.; Krasilnikova, Maria M.; Mirkin, Sergei M. (February 2009). "Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility". Nature Structural & Molecular Biology. 16 (2): 226–228. doi:10.1038/nsmb.1527. PMC 2837601. PMID 19136957.
  10. ↑ Mirkin, Ekaterina V.; Castro Roa, Daniel; Nudler, Evgeny; Mirkin, Sergei M. (9 May 2006). "Transcription regulatory elements are punctuation marks for DNA replication". Proceedings of the National Academy of Sciences. 103 (19): 7276–7281. Bibcode:2006PNAS..103.7276M. doi:10.1073/pnas.0601127103. PMC 1464333. PMID 16670199.
  11. ↑ "Faculty Highlights 2019-2020 | Department of Biology". as.tufts.edu. Retrieved 2022-11-08.
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