Set1 is a gene that codes for Histone-lysine N-methyltransferase and H3 lysine-4 specific proteins (H3K).[1] Set1 proteins can also be referred to as COMPASS proteins.[1] The first H3K4 methylase, Saccharomyces cerevisiae Set1/COMPASS, is highly conserved across a multitude of phylogenies.[2] The histone methylation facilitated by Set1 is required for cell growth and transcription silencing through the repression of RNA polymerase II.[3] The Set1C, COMPASS Complex, also aids in transcription elongation regulation and the maintenance of telomere length.[1]

References

  1. 1 2 3 "SET1 - Histone-lysine N-methyltransferase, H3 lysine-4 specific - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) - SET1 gene & protein". www.uniprot.org. Retrieved 2022-04-26.
  2. ↑ Shilatifard, Ali (2012). "The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis". Annual Review of Biochemistry. 81: 65–95. doi:10.1146/annurev-biochem-051710-134100. ISSN 0066-4154. PMC 4010150. PMID 22663077.
  3. ↑ Briggs, Scott D.; Bryk, Mary; Strahl, Brian D.; Cheung, Wang L.; Davie, Judith K.; Dent, Sharon Y. R.; Winston, Fred; Allis, C. David (2001-12-15). "Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae". Genes & Development. 15 (24): 3286–3295. doi:10.1101/gad.940201. ISSN 0890-9369. PMC 312847. PMID 11751634.


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