1999–2005

Sheth debuted as the lead in the ground-breaking 1999 film ABCD, starring opposite Aasif Mandvi and Faran Tahir. The film won Best Indie Feature at the Houston film festival^[13] and received critical acclaim from the likes of The Hollywood Reporter^[14] and Rolling Stone.^[15] Sheth was widely praised for her performance.^[16][17] Both the film and Sheth's character stirred considerable controversy. "But," Sheth responded, "that is exactly the kind of character I like to play. I want to tell the kinds of stories that people have a strong reaction to, positive or negative. It means it has touched them in some way and then I have done my job."^[18]

In 2001, she played a dancer in American Chai. The film won the Audience Award at the 2001 Slamdance Film Festival, with the New York Post describing it as a "slight but sweet film". Sheth went on to perform in a variety of roles in independent film and on network television, including the lead in the film Wings of Hope, for which she won Best Actress at Cinevue Film Festival.

2005–2010

Sheth on cover of CHI magazine in Summer 2005

In 2005, Sheth starred as Maya opposite Albert Brooks in Brooks' film Looking for Comedy in the Muslim World. Brooks conducted an extensive international search for the ideal actor to portray Maya, and says of Sheth, "Once I came across her, I watched everything that I could. I didn't care to look at anybody else…I just knew I had to put her in the film."^[19] The film was shot on location in India (Delhi and Agra).^[20] Sony Pictures Entertainment originally carried the film, but Brooks parted ways with them when he refused Sony's demand to remove the word "Muslim" from the title. The film was picked up and ultimately released by Warner Independent Pictures.^[21]

Following her success in Looking for Comedy in the Muslim World, Sheth won the recurring role of Martina in the NBC TV series The Singles Table, starring opposite Alicia Silverstone and John Cho. Six episodes were shot, but the series never aired.^[22] She also performed in the ensemble The Trouble With Romance and starred in the thriller First Fear opposite Sean Patrick Flanery.

Sheth's work brought her to the attention of the award-winning writer and director Shamim Sarif. Sheth starred opposite Lisa Ray in two lesbian themed films, I Can't Think Straight and The World Unseen, both written and directed by Sarif. I Can't Think Straight won more than ten Best Feature awards at film festivals around the world. The World Unseen premiered at the Toronto International Film Festival and went on to win four Best Feature awards internationally. The World Unseen, which was shot on location in South Africa, also swept the 2008 South African Film and Television Awards, winning eleven SAFTA's (South Africa's equivalent to the Oscars). Sheth won three Best Actress awards for her performance in The World Unseen. Both movies have achieved cult status, and have earned Sheth a large, loyal fan base for her portrayals of Leyla (I Can't Think Straight) and Amina (The World Unseen).

2010–present

Sheth went on to perform in Why Am I Doing This, and starred in Stalemate opposite Josh Randall and Burgess Jenkins, for which she was nominated for Best Actress at the 2011 Staten Island Film Festival. She guest starred in the popular television shows Nip/Tuck, Royal Pains and NCIS: Los Angeles, and provided the voices for Sumi and Shark in the animated feature film Johnny Bravo Goes to Bollywood, based on Cartoon Network's popular animated television series Johnny Bravo.

In 2011, Sheth starred opposite Mercedes Masöhn and Angela Zahra in Three Veils, which portrays three Middle Eastern women living in the United States. Even before it was released the film sparked intense controversy, and death threats were made against those involved with the production of the film.^[23] Three Veils has won numerous Best Feature awards at film festivals internationally, and Sheth's performance was widely acclaimed.

In 2012, Sheth continued to choose a variety of challenging roles in independent films. She starred opposite Lynn Chen and Parry Shen in Yes, We're Open, a sex comedy exploring open relationships. She again paired with Chen in Nice Girls Crew, which also stars Michelle Krusiec, and starred in The Wisdom Tree, a film blending science fiction, new age and mysticism. Sheth stepped behind the camera to co-produce Reign, a short film dramatizing how miscommunication can lead to war. She also starred in the film, which was written and directed by Kimberly Jentzen and shot by Oscar-nominated Cinematographer Jack Green. Reign received the Award of Merit from Best Shorts.^[24]

Sheth embarked on her acting career at a time when opportunities for South Asians, particularly Indian American women, in the industry were scarce. Despite the challenges, she became a trailblazer, breaking new ground. Her experience taught her that her ethnicity would often influence casting decisions, a factor she had not anticipated given her background and perspective. Many advised her to adopt a more "American" name, and she encountered obstacles when she chose to use her own name for performances. Over time, Sheth's body of work has showcased her acting prowess and her ability to embody a diverse range of characters, thanks in part to her skill with accents. Her achievements have not only advanced her career but have also paved the way for other South Asian actors to pursue opportunities in American film and television. Beyond her acting, Sheth actively supports underrepresented groups, including Asian Americans, by participating in festivals, workshops, and panels. Her advocacy addresses the challenges these communities face within the entertainment industry.^[25]

Humanitarian causes

While at New York University, Sheth was selected to be a part of AmeriCorps, a division of the Corporation for National and Community Service created by U.S. President Bill Clinton. Through Americorps, she worked at an inner-city high school, developing progressive lesson plans and activities, tutoring, and dealing with conflict resolution.^[27]

She participates in Big Brothers Big Sisters of Greater Los Angeles as a Big Sister, and also supports and promotes Women's Voices Now, an organization which encourage communities that are under-represented in American media, to make their voices heard.^[28]