| Small Cajal body specific RNA 23 | |
|---|---|
 Predicted secondary structure and sequence conservation of SCARNA23 | |
| Identifiers | |
| Symbol | SCARNA23 |
| Alt. Symbols | snoACA11 |
| Rfam | RF00427 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; scaRNA |
| Domain(s) | Eukaryota |
| GO | GO:0006396 GO:0015030 GO:0005730 |
| SO | SO:0000275 |
| PDB structures | PDBe |
Small Cajal body specific RNA 23 (also known as SCARNA23 or ACA11) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U1 spliceosomal RNA.
scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[1]
ACA11 belongs to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure, the conserved H/ACA-box motifs and is found associated with GAR1.[2] H/ACA snRNAs are predicted to guide the modification of uridines to pseudouridines in substrate RNAs however, no target RNA has been identified for scaRNA ACA11.[3]
References
- ↑ Darzacq X, Jády BE, Verheggen C, Kiss AM, Bertrand E, Kiss T (June 2002). "Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs". The EMBO Journal. 21 (11): 2746–56. doi:10.1093/emboj/21.11.2746. PMC 126017. PMID 12032087.
- ↑ Kiss AM, Jády BE, Bertrand E, Kiss T (July 2004). "Human box H/ACA pseudouridylation guide RNA machinery". Molecular and Cellular Biology. 24 (13): 5797–807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC 480876. PMID 15199136.
- ↑ Lestrade L, Weber MJ (January 2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Database issue): D158-62. CiteSeerX 10.1.1.105.7552. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836.