Susan Reutzel-Edens
Born
Susan Marie Reutzel
Alma materUniversity of Minnesota
Scientific career
InstitutionsEli Lilly & Company
Cambridge Crystallographic Data Centre
ThesisHydrogen-bonded imide aggregates : solid-state design, preparation, and characterization by solid-state NMR (1991)

Susan Reutzel-Edens FRSC is an American chemist who is the Head of Science at the Cambridge Crystallographic Data Centre. Her work considers solid state chemistry and pharmaceuticals. She is interested in crystal structure predictions. She serves on the editorial boards of CrystEngComm and Crystal Growth & Design.

Early life and education

Reutzel-Edens was a doctoral researcher at the University of Minnesota, where she studied the design and characterization of hydrogen-bonded imide aggregates. She worked in the laboratory of crystallographer Margaret C. Etter, and made use of solid state NMR.[1] During her doctorate, she investigated how hydrogen bonds could be used as design elements that guided the solid-state self assembly of organic molecules. She made use of the Cambridge Structural Database to unravel the complicated relationships between hydrate formation and crystal polymorphism.

Research and career

Reutzel-Edens joined Eli Lilly and Company, where she recognized that it would be challenging to identify and design increasingly complicated drug targets, and instead proposed the use of computation approaches. Through collaborations with the Cambridge Crystallographic Database, Reutzel-Edens founded the Lilly solid form design program.[2] Her research has considered crystal polymorphism and the crystal nucleation. She used computational approaches to identify commercially viable small molecule drug products.[3][4][5] To this end, Reutzel-Edens proposed the use of crystal structure prediction to identify pharmaceutical molecules to complement experimental investigations.[6] She has described Olanzapine as “an incredible molecule, a gift to crystal chemistry that keeps on giving,”.[7]

In 2018, Reutzel-Edens was appointed Fellow of the Royal Society of Chemistry. She serves on the editorial boards of CrystEngComm and Crystal Growth and Design.[8] In 2021 Reutzel-Edens joined the Cambridge Crystallographic Database as Head of Science.[9]

Selected publications

  • Aurora J Cruz-Cabeza; Susan M Reutzel-Edens; Joel Bernstein (24 September 2015). "Facts and fictions about polymorphism". Chemical Society Reviews. 44 (23): 8619–8635. doi:10.1039/C5CS00227C. ISSN 0306-0012. PMID 26400501. Wikidata Q38591930.
  • Stephenson GA; Forbes RA; Reutzel-Edens SM (1 May 2001). "Characterization of the solid state: quantitative issues". Advanced Drug Delivery Reviews. 48 (1): 67–90. doi:10.1016/S0169-409X(01)00099-0. ISSN 0169-409X. PMID 11325477. Wikidata Q34233912.
  • Sarah L. Price; Doris E Braun; Susan M Reutzel-Edens (12 April 2016). "Can computed crystal energy landscapes help understand pharmaceutical solids?". ChemComm. 52 (44): 7065–7077. doi:10.1039/C6CC00721J. ISSN 1364-548X. PMC 5486446. PMID 27067116. Wikidata Q38805031.

References

  1. ↑ Reutzel, Susan Marie (1991). Hydrogen-bonded imide aggregates: solid-state design, preparation, and characterization by solid-state NMR (Thesis). OCLC 29053127.
  2. ↑ Reutzel-Edens, Susan M. (2022-01-18). "Computer-aided solid form design". CrystEngComm. 24 (3): 431–433. doi:10.1039/D1CE90150H. ISSN 1466-8033.
  3. ↑ "Q&A with the new CCDC Head of Science - The Cambridge Crystallographic Data Centre (CCDC)". www.ccdc.cam.ac.uk. Retrieved 2022-06-21.
  4. ↑ "Crystal Growth & Design Webinar Series: Inspiring Medicines Design through Solid-State Chemistry". connect.acspubs.org. Retrieved 2022-06-21.
  5. ↑ Price, Sarah L.; Reutzel-Edens, Susan M. (2016-06-01). "The potential of computed crystal energy landscapes to aid solid-form development". Drug Discovery Today. 21 (6): 912–923. doi:10.1016/j.drudis.2016.01.014. ISSN 1359-6446. PMID 26851154.
  6. ↑ Price, Sarah L.; Braun, Doris E.; Reutzel-Edens, Susan M. (2016). "ChemInform Abstract: Can Computed Crystal Energy Landscapes Help Understand Pharmaceutical Solids?". ChemInform. 47 (29). doi:10.1002/chin.201629287. ISSN 0931-7597.
  7. ↑ Reutzel-Edens, S. M.; Bhardwaj, R. M. (2020-11-01). "Crystal forms in pharmaceutical applications: olanzapine, a gift to crystal chemistry that keeps on giving". IUCrJ. 7 (6): 955–964. doi:10.1107/S2052252520012683. ISSN 2052-2525. PMC 7642794. PMID 33209310.
  8. ↑ "Introducing our new Editorial Board Member: Susan Reutzel-Edens – CrystEngComm Blog". Retrieved 2022-06-21.
  9. ↑ "Public Profile - The Cambridge Crystallographic Data Centre (CCDC)". www.ccdc.cam.ac.uk. Retrieved 2022-06-21.
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