2004: two-year-old season

Sweet Catomine made her track debut in a maiden race over five and a half furlongs at Del Mar on July 31. Ridden by David Flores she started at odds of 5.7/1 and finished second, five lengths behind the winner She's Salty after racing on the wide outside until the stretch. Victor Espinoza took over the ride when the filly was moved up in class for the Grade I Del Mar Debutante Stakes over seven furlongs on August 28. Coupled with her stable companion Proposed, she started the 1.6/1 favorite ahead of the Landaluce Stakes winner Souvenir Gift. The filly started poorly but moved up into third place entering the straight and took the lead inside the final furlong to win by three quarters of a length from Souvenir Gift.^[5] Sweet Catomine was ridden by Corey Nakatani when the filly contested the Grade II Oak Leaf Stakes at Santa Anita Park on October 2 and started the 2/1 second favorite behind Splendid Blended, the five length winner of a maiden at Del Mar on September 6. After tracking the leaders in the early stages she moved up on the outside to take the lead on the final turn and drew away from her opponents to win by four lengths from Splendid Blended.^[6] Nakatani, riding the filly for the first time, described her as "awesome" whilst Canani explained "From the first time she ran until now, I think she's lost about 100 pounds ... baby fat. She used to be chunky, but now she's growing, developing mentally, and she's very athletic."^[7]

On October 31, Sweet Catomine contested the twenty-first edition of the Breeders' Cup Juvenile Fillies' run that year at Lone Star Park in Texas. With Nakatani again in saddle, she started the 2/1 favourite in a twelve-runner field which also included Sense of Style (winner of the Spinaway Stakes and Matron Stakes), Balletto (Frizette Stakes), Culinary (Arlington-Washington Lassie Stakes) and Runway Model (Alcibiades Stakes). She raced in seventh place in the early stages as first Higher World and then Sis City set the pace. When making a forward move on the penultimate turn she was blocked and stumbled before recovering to turn into the straight in fourth place. She took the lead well inside the final furlong and accelerated clear of her opponents to win by three and three quarter lengths from Balletto with Runway Model in third ahead of Sis City.^[8] Commenting of the filly's problems in running, Nakatani said "I was in a little tight but she was able to overcome that" whilst Canani described her as "a very special filly".^[9]

2005: three-year-old season

Sweet Catomine began her second season at Santa Anita Park on January 16 in the Grade III Santa Ysabel Stakes over one and one sixteenth of a mile. Ridden by Flores (Nakatani was serving a suspension), she started the 1/10 favorite despite conceding at least seven pounds to her four rivals and won by two and a half lengths from Pussycat Doll after taking the lead on the turn. Flores called the winner "a big horse with a lot of class" whilst Canani admitted that the filly was less than fully fit, commenting "This horse wasn't fit to run. I didn't put the screws down on her at all. But she's truly a champion. She's still developing".^[10] On March 13, Sweet Catomine, ridden by Nakatani, started the 1/5 favorite against six opponents in the Grade I Santa Anita Oaks over the same course and distance. After racing in sixth place for the first half mile, the filly moved up on the outside, took the lead on the final turn and accelerated clear in the stretch to win by three lengths from Memorette, with a gap of five lengths back to She Sings in third place. After the race Nakatani called the winner "the best filly I ever rode" whilst Canani was even more effusive, calling her "the best filly who ever lived".^[11]

On April 9, Sweet Catomine was matched against colts for the first time as she attempted to become the fourth filly, after Ciencia, Silver Spoon and Winning Colors to win the nine furlong Santa Anita Derby. Canani had been describing the filly as a Kentucky Derby contender, but in the days before the race she reportedly bled after exercise and suffered from soreness in a foot as well as coming into season. Ridden by Nakatani, she started favorite and recovered from a bump on the backstretch to reach fifth place entering the straight. She could make no further progress, however, and finished fifth behind Buzzards Bay, General John B, Wilko and Giacomo. Wygod said after the race "In my heart I felt not to run but yesterday we made up our mind", whilst Nakatani commented "that's not her, she was just flat".^[12]

Sweet Catomine's performance in the Santa Anita Derby caused controversy, as some commentators believed that the betting public had not been made aware of the filly's training problems and that she had been sent for treatment at an Equine Medical Center in Los Olivos three days before the race.^[13] As the California Horse Racing Board launched an investigation, the Wygods removed the filly from the care of Canani who had been quoted as saying that she had been "doing great... running super" immediately before the race and transferred her to the stable of John Shirreffs.^[14] On April 12 the CHRB filed complaints against Martin Wygod and Dean Kerhoff, a transport worker who had driven the filly to Los Olivos after alleging that the details of her departure from the track and return from the medical facility had been "deliberately falsified".^[15] After a hearing before the racecourse stewards at Hollywood Park, the complaints were dismissed. Wygod's attorney Richard Kendall, blamed the media for the controversy saying "It was a junk misunderstanding. Journalists took at face value what they saw without asking the hard questions." Wygod himself commented My name has been dragged through the mud. It was terrible for both my wife and my kids, who I had hoped would continue to become more involved in the game".^[16]

In the meantime, Sweet Catomine had been retired from racing on April 21 after undergoing a veterinary assessment at Shirreffs' stable. With the hearing still pending, Wygod declined to discuss the details but said "I have decided to retire her and breed her to A.P. Indy. I wanted to retire her while she was sound. She will be shipped to Kentucky in the next two days and will be at Mill Ridge Farm."^[17]