TAF1C
Identifiers
AliasesTAF1C, MGC:39976, SL1, TAFI110, TAFI95, TATA-box binding protein associated factor, RNA polymerase I subunit C
External IDsOMIM: 604905 MGI: 109576 HomoloGene: 21163 GeneCards: TAF1C
Orthologs
SpeciesHumanMouse
Entrez

9013

21341

Ensembl

ENSG00000103168

ENSMUSG00000031832

UniProt

Q15572

Q6PDZ2

RefSeq (mRNA)

NM_021441
NM_001378901

RefSeq (protein)

NP_067416
NP_001365830

Location (UCSC)Chr 16: 84.18 – 84.19 MbChr 8: 120.32 – 120.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TATA box-binding protein-associated factor RNA polymerase I subunit C is an enzyme that in humans is encoded by the TAF1C gene.[5][6]

Function

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.[6]

Interactions

TAF1C has been shown to interact with UBTF.[7][8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000103168 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031832 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R (1994). "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits". Science. 266 (5193): 1966–72. Bibcode:1994Sci...266.1966C. doi:10.1126/science.7801123. PMID 7801123.
  6. 1 2 "Entrez Gene: TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa".
  7. Voit R, Grummt I (November 2001). "Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13631–6. Bibcode:2001PNAS...9813631V. doi:10.1073/pnas.231071698. PMC 61092. PMID 11698641.
  8. Zhai W, Comai L (August 2000). "Repression of RNA polymerase I transcription by the tumor suppressor p53". Mol. Cell. Biol. 20 (16): 5930–8. doi:10.1128/MCB.20.16.5930-5938.2000. PMC 86070. PMID 10913176.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.