TANK
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTANK, I-TRAF, ITRAF, TRAF2, TRAF family member associated NFKB activator
External IDsOMIM: 603893 MGI: 107676 HomoloGene: 3081 GeneCards: TANK
Orthologs
SpeciesHumanMouse
Entrez

10010

21353

Ensembl

ENSG00000136560

ENSMUSG00000064289

UniProt

Q92844
Q6NW12

P70347

RefSeq (mRNA)

NM_001199135
NM_004180
NM_133484

RefSeq (protein)

NP_001186064
NP_004171
NP_597841
NP_001186064.1

Location (UCSC)Chr 2: 161.14 – 161.24 MbChr 2: 61.58 – 61.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TRAF family member-associated NF-kappa-B activator is a protein that in humans is encoded by the TANK gene.[5][6][7]

Function

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Two transcript variants encoding different isoforms have been found for this gene.[7]

Interactions

TANK (gene) has been shown to interact with TANK-binding kinase 1,[8][9] IKBKE,[10] TRAF2,[5][8][9][10] IKBKG[11] and TRAF3.[5][8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000136560 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000064289 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 3 Rothe M, Xiong J, Shu HB, Williamson K, Goddard A, Goeddel DV (August 1996). "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction". Proceedings of the National Academy of Sciences of the United States of America. 93 (16): 8241–6. Bibcode:1996PNAS...93.8241R. doi:10.1073/pnas.93.16.8241. PMC 38654. PMID 8710854.
  6. Kaye KM, Devergne O, Harada JN, Izumi KM, Yalamanchili R, Kieff E, Mosialos G (October 1996). "Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein". Proceedings of the National Academy of Sciences of the United States of America. 93 (20): 11085–90. Bibcode:1996PNAS...9311085K. doi:10.1073/pnas.93.20.11085. PMC 38288. PMID 8855313.
  7. 1 2 "Entrez Gene: TANK TRAF family member-associated NFKB activator".
  8. 1 2 3 Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
  9. 1 2 Pomerantz JL, Baltimore D (December 1999). "NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase". The EMBO Journal. 18 (23): 6694–704. doi:10.1093/emboj/18.23.6694. PMC 1171732. PMID 10581243.
  10. 1 2 Nomura F, Kawai T, Nakanishi K, Akira S (March 2000). "NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation". Genes to Cells. 5 (3): 191–202. doi:10.1046/j.1365-2443.2000.00315.x. PMID 10759890. S2CID 8489218.
  11. Chariot A, Leonardi A, Muller J, Bonif M, Brown K, Siebenlist U (October 2002). "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases". The Journal of Biological Chemistry. 277 (40): 37029–36. doi:10.1074/jbc.M205069200. PMID 12133833.

Further reading

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.