TBL3
Identifiers
AliasesTBL3, SAZD, UTP13, transducin beta like 3
External IDsOMIM: 605915 MGI: 2384863 HomoloGene: 4711 GeneCards: TBL3
Orthologs
SpeciesHumanMouse
Entrez

10607

213773

Ensembl

ENSG00000183751

ENSMUSG00000040688

UniProt

Q12788

Q8C4J7

RefSeq (mRNA)

NM_006453

NM_145396

RefSeq (protein)

NP_006444

NP_663371

Location (UCSC)Chr 16: 1.97 – 1.98 MbChr 17: 24.92 – 24.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transducin beta-like protein 3 is a protein that in humans is encoded by the TBL3 gene.[5][6]

The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene has multiple polyadenylation sites. It might have multiple alternatively spliced transcript variants but the variants have not been fully described yet.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000183751 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040688 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Weinstat-Saslow DL, Germino GG, Somlo S, Reeders ST (Mar 1994). "A transducin-like gene maps to the autosomal dominant polycystic kidney disease gene region". Genomics. 18 (3): 709–11. doi:10.1016/S0888-7543(05)80380-5. PMID 8307582.
  6. 1 2 "Entrez Gene: TBL3 transducin (beta)-like 3".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.