TERF2IP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTERF2IP, DRIP5, RAP1, TERF2 interacting protein
External IDsOMIM: 605061 MGI: 1929871 HomoloGene: 10357 GeneCards: TERF2IP
Orthologs
SpeciesHumanMouse
Entrez

54386

57321

Ensembl

ENSG00000166848

ENSMUSG00000033430

UniProt

Q9NYB0

Q91VL8

RefSeq (mRNA)

NM_018975

NM_020584

RefSeq (protein)

NP_061848

NP_065609

Location (UCSC)Chr 16: 75.65 – 75.76 MbChr 8: 112.74 – 112.75 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Telomeric repeat-binding factor 2-interacting protein 1 also known as repressor activator protein 1 (Rap1) is a protein that in humans is encoded by the TERF2IP gene.[5][6]

Interactions

TERF2IP has been shown to interact with Ku80,[7] Rad50[7] and TERF2.[5][7][8] Upon interaction, TERF2IP/TERF2 complex has been shown to bind to telomeric junction sites with higher affinity[9]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000166848 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033430 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Li B, Oestreich S, de Lange T (May 2000). "Identification of human Rap1: implications for telomere evolution". Cell. 101 (5): 471–83. doi:10.1016/S0092-8674(00)80858-2. PMID 10850490. S2CID 7956545.
  6. "Entrez Gene: TERF2IP telomeric repeat binding factor 2, interacting protein".
  7. 1 2 3 O'Connor MS, Safari A, Liu D, Qin J, Songyang Z (July 2004). "The human Rap1 protein complex and modulation of telomere length". The Journal of Biological Chemistry. 279 (27): 28585–91. doi:10.1074/jbc.M312913200. PMID 15100233.
  8. Zhu XD, Küster B, Mann M, Petrini JH, de Lange T (July 2000). "Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres". Nature Genetics. 25 (3): 347–52. doi:10.1038/77139. PMID 10888888. S2CID 6689794.
  9. Arat NÖ, Griffith JD (December 2012). "Human Rap1 interacts directly with telomeric DNA and regulates TRF2 localization at the telomere". The Journal of Biological Chemistry. 287 (50): 41583–94. doi:10.1074/jbc.M112.415984. PMC 3516710. PMID 23086976.

Further reading


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