TLE4

TLE4
Identifiers
Aliases	TLE4, BCE-1, BCE1, E(spI), ESG, ESG4, GRG4, Grg-4, transducin like enhancer of split 4, TLE family member 4, transcriptional corepressor, E(spl)
External IDs	OMIM: 605132 MGI: 104633 HomoloGene: 38259 GeneCards: TLE4
Gene location (Human)
Chr.	Chromosome 9 (human)
End	79,726,882 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	14,575,415 bp
RNA expression pattern
	Top expressed in
	optic nerve; ; endothelial cell; ; corpus callosum; ; inferior olivary nucleus; ; inferior ganglion of vagus nerve; ; Region I of hippocampus proper; ; bone marrow cells; ; external globus pallidus; ; subthalamic nucleus; ; germinal epithelium;
	Top expressed in
	renal corpuscle; ; medullary collecting duct; ; superior cervical ganglion; ; suprachiasmatic nucleus; ; conjunctival fornix; ; nucleus accumbens; ; retinal pigment epithelium; ; olfactory tubercle; ; pineal gland; ; iris;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; chromatin binding; protein binding; transcription corepressor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; molecular function;
Cellular component	nucleus; nucleoplasm; transcription regulator complex; beta-catenin-TCF complex;
Biological process	negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; Wnt signaling pathway; transcription, DNA-templated; beta-catenin-TCF complex assembly; cellular response to leukemia inhibitory factor; biological process; negative regulation of canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	7091
	21888
	ENSG00000106829
	ENSMUSG00000024642
	Q04727
	Q62441
NM_001282748; NM_001282749; NM_001282753; NM_001282760; NM_007005;
	NM_001351541; NM_001351542; NM_001351543; NM_001351546; NM_001351547; NM_001351550; NM_001351552; NM_001351558; NM_001351560; NM_001351562; NM_001351563; NM_001351564; NM_001351556
	NM_011600; NM_001302947; NM_001302950; NM_001302951
NP_001269677; NP_001269678; NP_001269682; NP_001269689; NP_008936;
	NP_001338470; NP_001338471; NP_001338472; NP_001338475; NP_001338476; NP_001338479; NP_001338481; NP_001338487; NP_001338489; NP_001338491; NP_001338492; NP_001338493; NP_001338485
	NP_001289876; NP_001289879; NP_001289880; NP_035730
	Wikidata
View/Edit Human	View/Edit Mouse

Transducin-like enhancer protein 4 is a protein that in humans is encoded by the TLE4 gene.^[5]^[6]

Interactions

TLE4 has been shown to interact with PAX5.^[7]^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000106829 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024642 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Miyasaka H, Choudhury BK, Hou EW, Li SS (August 1993). "Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein". European Journal of Biochemistry. 216 (1): 343–52. doi:10.1111/j.1432-1033.1993.tb18151.x. PMID 8365415.
↑ "Entrez Gene: TLE4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)".
↑ Eberhard D, Jiménez G, Heavey B, Busslinger M (May 2000). "Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family". The EMBO Journal. 19 (10): 2292–303. doi:10.1093/emboj/19.10.2292. PMC 384353. PMID 10811620.
↑ Milili M, Gauthier L, Veran J, Mattei MG, Schiff C (August 2002). "A new Groucho TLE4 protein may regulate the repressive activity of Pax5 in human B lymphocytes". Immunology. 106 (4): 447–55. doi:10.1046/j.1365-2567.2002.01456.x. PMC 1782747. PMID 12153506.

Stifani S, Blaumueller CM, Redhead NJ, Hill RE, Artavanis-Tsakonas S (October 1992). "Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins". Nature Genetics. 2 (2): 119–27. doi:10.1038/ng1092-119. PMID 1303260. S2CID 32142845.
Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (October 1999). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (5): 337–45. doi:10.1093/dnares/6.5.337. PMID 10574462.
Eberhard D, Jiménez G, Heavey B, Busslinger M (May 2000). "Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family". The EMBO Journal. 19 (10): 2292–303. doi:10.1093/emboj/19.10.2292. PMC 384353. PMID 10811620.
Milili M, Gauthier L, Veran J, Mattei MG, Schiff C (August 2002). "A new Groucho TLE4 protein may regulate the repressive activity of Pax5 in human B lymphocytes". Immunology. 106 (4): 447–55. doi:10.1046/j.1365-2567.2002.01456.x. PMC 1782747. PMID 12153506.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Heimbucher T, Murko C, Bajoghli B, Aghaallaei N, Huber A, Stebegg R, Eberhard D, Fink M, Simeone A, Czerny T (January 2007). "Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors". Molecular and Cellular Biology. 27 (1): 340–51. doi:10.1128/MCB.00811-06. PMC 1800652. PMID 17060451.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000106829 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024642 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8365415-5] Miyasaka H, Choudhury BK, Hou EW, Li SS (August 1993). "Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein". European Journal of Biochemistry. 216 (1): 343–52. doi:10.1111/j.1432-1033.1993.tb18151.x. PMID 8365415.

[entrez-6] "Entrez Gene: TLE4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)".

[pmid10811620-7] Eberhard D, Jiménez G, Heavey B, Busslinger M (May 2000). "Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family". The EMBO Journal. 19 (10): 2292–303. doi:10.1093/emboj/19.10.2292. PMC 384353. PMID 10811620.

[pmid12153506-8] Milili M, Gauthier L, Veran J, Mattei MG, Schiff C (August 2002). "A new Groucho TLE4 protein may regulate the repressive activity of Pax5 in human B lymphocytes". Immunology. 106 (4): 447–55. doi:10.1046/j.1365-2567.2002.01456.x. PMC 1782747. PMID 12153506.

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Interactions

References

Further reading