TRIM38

TRIM38
Identifiers
Aliases	TRIM38, RNF15, RORET, tripartite motif containing 38
External IDs	MGI: 2684869 HomoloGene: 48427 GeneCards: TRIM38
Gene location (Human)
Chr.	Chromosome 6 (human)
End	25,991,231 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	23,975,511 bp
RNA expression pattern
	Top expressed in
	cardia; ; renal medulla; ; pylorus; ; nipple; ; superior surface of tongue; ; ventral tegmental area; ; external globus pallidus; ; vena cava; ; trigeminal ganglion; ; inferior ganglion of vagus nerve;
	Top expressed in
	morula; ; blastocyst; ; jejunum; ; duodenum; ; colon; ; secondary oocyte; ; spermatid; ; testicle; ; ileum; ; quadriceps femoris muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	zinc ion binding; signal transducer activity; metal ion binding; protein binding; transferase activity;
Cellular component	cytosol; intracellular anatomical structure;
Biological process	immune system process; interferon-gamma-mediated signaling pathway; positive regulation of DNA-binding transcription factor activity; positive regulation of NF-kappaB transcription factor activity; protein ubiquitination; positive regulation of I-kappaB kinase/NF-kappaB signaling; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	10475
	214158
	ENSG00000112343
	ENSMUSG00000064140
	O00635
	Q5SZ99
	NM_006355
	NM_001029935
	NP_006346
	NP_001025106
	Wikidata
View/Edit Human	View/Edit Mouse

Tripartite motif containing 38 is a protein that in humans is encoded by the TRIM38 gene. ^[5]

Function

This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Jul 2012].

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000112343 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000064140 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Tripartite motif containing 38". Retrieved 2018-03-21.

Liu X, Lei X, Zhou Z, Sun Z, Xue Q, Wang J, Hung T (February 2011). "Enterovirus 71 induces degradation of TRIM38, a potential E3 ubiquitin ligase". Virol. J. 8: 61. doi:10.1186/1743-422X-8-61. PMC 3048563. PMID 21306652.
Liu XL, Lei XB, Wang JW, Hong T (February 2011). "[Identification A novel protein TRIM38 that activate NF-kappaB signaling pathways]". Zhonghua Shi Yan He Lin Chuang Bing du Xue Za Zhi (in Chinese). 25 (1): 60–2. PMID 21789858.
Xue Q, Zhou Z, Lei X, Liu X, He B, Wang J, Hung T (2012). "TRIM38 negatively regulates TLR3-mediated IFN-β signaling by targeting TRIF for degradation". PLOS ONE. 7 (10): e46825. Bibcode:2012PLoSO...746825X. doi:10.1371/journal.pone.0046825. PMC 3466175. PMID 23056470.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000112343 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000064140 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Tripartite motif containing 38". Retrieved 2018-03-21.

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Function

References

Further reading