EIPR1
Identifiers
AliasesEIPR1, TSSC1, tumor suppressing subtransferable candidate 1, EIPR-1, EARP complex and GARP complex interacting protein 1
External IDsOMIM: 608998 MGI: 1289332 HomoloGene: 2481 GeneCards: EIPR1
Orthologs
SpeciesHumanMouse
Entrez

7260

380752

Ensembl

ENSG00000032389

ENSMUSG00000036613

UniProt

Q53HC9

Q8K0G5

RefSeq (mRNA)

NM_003310
NM_001330530
NM_001330531

NM_201357
NM_001379229
NM_001379230

RefSeq (protein)

NP_001317459
NP_001317460
NP_003301

NP_958745
NP_001366158
NP_001366159
NP_001390093
NP_001390094

Location (UCSC)Chr 2: 3.19 – 3.38 MbChr 12: 28.8 – 28.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein TSSC1 is a protein that in humans is encoded by the TSSC1 gene.[5][6][7]

Function

This gene has been reported[8] as one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene may reside on chromosome 2 rather than chromosome 11.[7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000032389 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036613 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Hu RJ, Lee MP, Connors TD, Johnson LA, Burn TC, Su K, Landes GM, Feinberg AP (November 1997). "A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes". Genomics. 46 (1): 9–17. doi:10.1006/geno.1997.4981. PMID 9403053.
  6. ↑ Scelfo R, Sabbioni S, Barbanti-Brodano G, Negrini M (Mar 1999). "Subchromosomal assignment1 of the TSSC1 gene to human chromosome band 11p15.5 near the HBB gene cluster". Cytogenetics and Cell Genetics. 83 (1–2): 52–3. doi:10.1159/000015123. PMID 9925925. S2CID 9646786.
  7. 1 2 "Entrez Gene: TSSC1 tumor suppressing subtransferable candidate 1".
  8. ↑ Hu RJ, Lee MP, Connors TD, et al. (November 1997). "A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes". Genomics. 46 (1): 9–17. doi:10.1006/geno.1997.4981. PMID 9403053.

Further reading

  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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