Targanta Therapeutics
TypePublic (Nasdaq: TARG)
IndustryBiotechnology
Founded1997 (as PhageTech Inc.)
Defunct2009 (2009)
FateAcquired
SuccessorThe Medicines Company
HeadquartersCambridge, Massachusetts
Number of employees
82 9/24/07 per S-1
Websitehttp://www.themedicinescompany.com/

Targanta Therapeutics Corporation was a biopharmaceutical company headquartered in Cambridge, Massachusetts. The company also had operations in Indianapolis, Montreal and Toronto. Targanta completed its initial public offering on October 9, 2007[1] and traded on the Nasdaq market under the symbol: TARG. Targanta was acquired by The Medicines Company in 2009.[2]

Development Programs

Targanta’s lead product candidate was oritavancin; a novel, semi-synthetic glycopeptide antibiotic being developed to treat serious Gram-positive infections in the hospital and other institutional settings. Oritavancin was originally discovered and developed by Eli Lilly; Targanta acquired worldwide rights to oritavancin from InterMune in late 2005.[3] Data presented at the 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in September 2007 demonstrated that oritavancin possesses potent and rapid bactericidal activity in vitro against a broad spectrum of both resistant and susceptible Gram-positive bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Enterococci, Clostridium difficile and Streptococci.[4] Results have been presented but not yet published from two pivotal Phase 3 clinical trials testing the efficacy of oritavancin for the treatment of Complicated skin and skin-structure infections (cSSSI) caused by Gram-positive bacteria. The primary endpoints of both studies were successfully met, with oritavancin achieving efficacy with fewer days of therapy than the comparator agents (vancomycin followed by cephalexin). In addition, oritavancin showed a significantly improved safety profile with a 19.2 percent relative reduction in the overall incidence of adverse events versus vancomycin/cephalexin (p<0.001) in the second and larger pivotal trial.[5]

Targanta also developed a novel drug discovery platform to generate molecules that deliver antibiotics directly to the bone. Also at the 47th ICAAC meeting in September 2007, Targanta presented the first in vivo pre-clinical data on candidates from this program, demonstrating efficacy of its rifabutin-bisphosphonate prodrug (TT99000647) in a rabbit osteomyelitis model.[6]

References

  1. ↑ IPO News Archives
  2. ↑ The Medicines Company Completes Acquisition of Targanta Therapeutics Corporation, February 26, 2009
  3. ↑ Targanta Revives Oritavancin: Next Weapon Against cSSSI? BioWorld Today, November 26, 2007
  4. ↑ ICAAC 2007 Posters: E-1612 “In Vitro Activity Profile of Oritavancin against a Broad Spectrum of Aerobic and Anaerobic Bacterial Pathogens”/E -1613 “In Vitro Activity Profile of Oritavancin (ORI) Against Organisms Demonstrating Key Resistance Profiles to Other Antimicrobial Agents”/E-1614 “In vitro Time Kill Studies of Oritavancin against Drug-resistant Isolates of Staphylococcus aureus and Enterococci”/E-1615 “Anti-Enterococcal Activity Profile of Oritavancin, a Potent Lipoglycopeptide under Development for Use Against Gram-Positive Infections”/E-1616 “Anti-Streptococcal Activity Profile of Oritavancin, a Potent Lipoglycopeptide under Development for Use Against Gram-Positive Infections”/E-1617 “In Vitro Activity Profile of Oritavancin (ORI) Against Resistant Staphylococcal Populations From a Recent Surveillance Initiative”/E-1620 “Pharmacokinetic Concentrations of Oritavancin Kill Stationary-Phase and Biofilm Staphylococcus aureus In Vitro.” / Targanta Press Release September 19, 2007 Archived July 13, 2011, at the Wayback Machine
  5. ↑ ICAAC 2003 Late-breaker poster: "Phase III Trial Comparing 3-7 days of Oritavancin vs. 10-14 days of Vancomycin/Cephalexin in the Treatment of Patients with Complicated Skin and Skin Structure Infections (cSSSI)" / InterMune Press Release September 15, 2003 Archived July 14, 2012, at archive.today
  6. ↑ ICAAC 2007 Poster “In Vivo Efficacy of a New Osteotropic Prodrug in a Rabbit Model of Chronic Osteomyelitis” / Targanta Press Release, September 19, 2007 Archived July 13, 2011, at the Wayback Machine
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