Kimble is riding on a bus when the police stop it to capture an escaped convict, who takes a woman hostage. Kimble disarms the man, but gets stabbed during the struggle while the convict is shot dead. Not knowing his true identity, the police treat Kimble as a hero and transport him to a prison hospital for treatment. When two inmates recognize Kimble, they threaten to reveal his identity unless he assists them in their drug-smuggling scheme.

Kimble breaks up with a local woman he has been dating, Laurel Harper, and she angrily storms out of the bar they are in and into the night. The next morning, Laurel is found on an abandoned road unconscious and badly beaten. While she is taken to a hospital for treatment, Laurel's paranoid and suspicious sister, Sheila, convinces the police to hold Kimble for questioning.

Sal Mitchell is a scam artist posing as a psychic who goes on TV to prove that he knows where Kimble will appear next after he recognizes Kimble working at a gas station. The con artist's girlfriend, Joan, then contacts Kimble by pretending to know the whereabouts of the one-armed man hoping Kimble will go to a place they say he is so the police can arrest him.

Kimble telephones his sister, Donna, and she reveals that she had received a letter from James Eckhardt, a former U.S. Army captain who also saw the one-armed man fleeing from the Kimble's house on the night of Helen's murder. Concerned about cranks, Donna had a private detective verify that Eckhardt is legitimate, and Kimble meets with him in Chicago. Eckhardt had been reluctant to testify for Kimble but upon meeting him - and seeing the man genuinely needs his help - agrees to testify. Kimble's lawyer Burton Green who defended him during the trial meets with Eckhardt and is positive that his testimonial is legit. He advises Kimble to turn himself in so he can begin work on an appeal. However Kimble refuses as he is determined to find the one armed man first. Unbeknownst to them, a convict in prison for drug dealing comes forward as a witness and reveals to Gerard that he used to sell morphine to Eckhardt and that Eckhardt was on his way to see him that night to buy some drugs, which is enough for Gerard to discredit Eckhardt's testimony. When Donna, and her lawyer Burt Green learn of this, Donna must contact Eckhardt to have him stop Kimble from turning himself in.

Guest Stars: Marion Ross as Marion Eckhardt, Charles Aidman as Capt. James Eckhardt, Frank Aletter as Burton Green, Tommy Rettig as J.J. Eickhardt, Chris Alcaide as Lieutenant Horvath, and Jacqueline Scott as Donna Taft.

While working as a steward at a remote desert resort, Kimble is unaware that the area is a top-secret government test site for chemical weapons. When Kimble tries to leave, he gets mistaken for a spy by Major Beck, the head of the project. When several staff members, including the staff physician, suffer from a resulting chemical explosion, Kimble is forced to care for the wounded, unaware that Beck still plans to turn him into the army general leading the project.

Kimble is working as a chauffeur for George Forster, a successful contractor who returns to his small Midwestern home town with big plans for the community. Kimble discovers that one of the townspeople is planning to kill Forster and he must find out who it is.

Kimble responds to a newspaper ad for a driver and is hired to drive Peggy Franklin and her 10-year-old daughter, Nancy, to California. What Kimble does not realize is that Peggy has abducted Nancy from her ex-husband, a pathologist named Dean Franklin. Before leaving, Nancy removes a rabbit from Dean's research lab, unaware that the rabbit has meningitis. When Nancy contracts the sickness, Kimble risks keeping his secret safe to save the little girl.

Running from the police, Kimble hides out at a farm owned by a local country doctor, named Josephus Adams, who treats his patients with honey and a reassuring word. After one elderly woman under Adams care dies from a protracted bronchial infection, an angry Kimble intervenes and tries to help the patients. In the meantime, Adams wife, Marianne, stumbles upon Kimble's identity and tries to use that to her own advantage. When Adams teenage niece, Sharon, falls into a coma after having an allergic reaction to a bee stings, Kimble risks his freedom to take her away from Adams to a hospital for treatment.

Guest Stars: Herschel Bernardi as Captain Ames and Barbara Rush as Marie Gerard.

Kimble reluctantly becomes involved with Stella Savano, the sister of George Savano, who runs the trucking company where Kimble works. Stella is an emotionally disturbed woman with a dangerous obsession with Johnny, the adopted eight-year-old son of Jesse Stangel, Kimble's co-worker. Kimble learns that Stella is actually Johnny's mother, but Stella becomes so delusional that she thinks that Kimble is Johnny's father, and that the three are destined to be together as a family -- a dangerous proposition for Kimble, who has been warned by his boss to stay away from Stella.

Kimble is working as a custodian for the Saturday Morning Camp, a weekend camp run by Tony and Carole Burnell. Things become complicated when two police officers are found beaten to death near the camp. The police recruit Tony, a former policeman, to interrogate a local juvenile delinquent who is the main suspect in the killings. Tony, however, reluctantly begins to suspect Kimble, after a box containing the badges of the murdered policemen shows up in Kimble's apartment. Unknown to everyone, the real killer is Tony, who has been murdering police officers during blackouts, and has no memory of the killings afterwards. Subconsciously, Tony blames the police for the death of his father, a policeman who was sent to prison on a trumped-up murder charge and then killed by dirty cops during a prison riot.

After losing his wallet, Kimble steals another wallet to pay for his train fare. The wallet belongs to R.T. Unger, who owns a local dairy. Kimble works as a dishwasher at a local diner in order to repay the debt, but when Unger finds his wallet missing, he calls the police. Kimble goes to Unger's house and gives back the wallet and money to Unger's daughter, Betty Jo, who is pregnant by Neil, a disreputable youth who works at Unger's dairy. Unger offers Neil $500 to leave town, but when Neil demands $1,000, their argument turns into a fistfight where Kimble walks in and sees Neil kill Unger.

In rural Wyoming, Kimble seeks refuge from the local constable at a small motel run by Lois Carter, a young widow who hires him as a handyman. Kimble soon befriends Lois' savant son Kenny, who protects Kimble from the police when they arrive looking for him.

Kimble arrives in Hempstead Mills, West Virginia to assist Andrew McCallister, his longtime mentor who is dying from lung cancer. McCallister's vigorous anti-smog campaign has earned him a reputation as a local crackpot, but the old man plans to go out with a bang by having a bomb hidden in a package and delivered to the local factory. When McCallister discovers that a group of school children will be inside the factory during a field trip at the time of the explosion, he dispatches Kimble to evacuate the building and deactivate the bomb before time runs out.

Jane Washburn, an undercover policewoman, witnesses three youths beat up and rob Kimble. She tends to him, but becomes suspicious after he declines to report his mugging to the police. Jane handcuffs herself to Kimble to arrest him, but he manages to flee the area with her. After Jane sprains her ankle after hopping off a freight train, they break into an abandoned farm house so Kimble can tend to her as well as saw off the handcuffs. Soon, the family that lives there returns and Kimble is held at gunpoint by the sadistic patriarch of the family.

Gary Keller, a promising art student, tests his new rifle by firing a random shot, which instantly kills his mentor, the town minister, who happens to be driving on a road right in the line of fire. Kimble is in the car with him because the minister had given a ride to him. The car crashes and Kimble hobbles away. A guilt-ridden Gary wants to confess, but his father, Steve, refuses to let him do so because it will destroy his promising career. The police arrive on the scene and after spotting Kimble, they think he is the killer. They notify Gerard, who was already in New Mexico as Kimble had been spotted upstate four days previously. Gerard arrives in town to track Kimble down; meanwhile, Steve decides to take matters into his own hands by finding Kimble and hiding him so he does not implicate his son.

Guest Stars: Beau Bridges as Gary Keller, Telly Savalas as Steve Keller, and Ellen Corby as Mrs. Barlow.

After learning of the death of his father, Kimble contacts Donna and her husband, Len. Donna is distraught and desperately wants to meet Richard, and they arrange a meeting in Fort Wayne, Indiana. Donna and Len go there and check into a hotel under assumed names, but Donna is recognized by Mike Ballinger, the former prosecuting attorney at Kimble's trial; Ballinger is running for governor and his top aide persuades him that helping apprehend Kimble will help him politically. Ballinger calls Gerard to set up a trap but Ballinger's wife Harriet, fed up with Mike's nonstop campaigning and a resultant growing addiction to stimulants, hides Kimble and helps him meet Donna and Len.

Guest Stars: Jacqueline Scott as Donna Taft, Lin McCarthy as Len Taft, James Daly as Michael Ballinger, and Joanne Linville as Harriet Ballinger.

Gerard tracks Kimble to a migrant community in South Texas where he finally captures Kimble, who attempts to flee by train. A violent hurricane strikes the area and forces both of them to seek shelter in a fragile barn where most of the farm workers are gathered. When Gerard is badly injured when the roof collapses on him, Kimble, to the astonishment of the workers, actually helps try to save the lieutenant by helping transport him to another building where he pleads for a blood donor to save Gerard's life.

Guest Stars: John McIntire as Lester Kelly, Jeanette Nolan as Naomi Kelly, Lonny Chapman as Jock Sims, Tim McIntire as Jonesie and Bonnie Beecher as Kate

After witnessing a small plane crash, Kimble rescues the pilot and the two passengers, senatorial candidate Glenn Madison, and his assistant, Pat Haynes. Glenn's PR man, Russ Haynes, Pat's husband, arranges for a sketch artist to draw a portrait of Glenn's rescuer who had left the scene. Russ locates Kimble and brings him to the Madison estate for Glenn to congratulate him for saving his life. Meanwhile, Glenn's wife, Claire, recognizes Kimble, and threatens to turn him in unless he tells her of the person that Glenn was seeing, aware of her husband's long history of infidelity. Kimble claims not to know anything. When Kimble confronts Pat, she admits to her affair with Glenn. Claire overhears the conversation and decides to destroy her husband's image.

While working as a chauffeur in Denver, Colorado, Kimble reluctantly covers for teenager Laurie Ryder (guest star Susan Albert) after she dents her father's car, but Kimble flees after discovering that Laurie was involved in a hit-and-run. After learning Kimble's identity, Laurie's father, Dr. Mark Ryder (guest star Melvyn Douglas), summons Gerard, along with the entire Kimble file, to Denver, where he introduces Gerard to the 2130, a computer that can help capture Kimble by determining a pattern to his travels.

Kimble meets Joe Tucker, another fugitive from justice, who claims that he was wrongly convicted of embezzlement four years earlier and wants to kill Charlie Fletcher, the man Tucker suspects is the real culprit. When Kimble discovers that Joe suffers from a dangerous illness, he tries to help him, but Tucker, delirious with the illness, escapes and tracks down Fletcher at his house, where he confronts him with a gun until Kimble helps prove Tucker's innocence.

Kimble, working as a bartender in a local diner, becomes involved with waitress Susan Cartwright, but their growing romance is complicated by the arrival of Susan's orphaned nephew Gary, who is trying to break into a small group of local boys. When Gary recognizes Kimble, he tells the boys of his find and they decide to capture Kimble with a rifle they purchase from a magazine ad. Meanwhile, Susan's social worker, Mr. Shaw (played by Michael Strong), investigates Susan and her ability to raise Gary.

Guest Stars: Kurt Russell as Eddie, Lois Nettleton as Susan Cartwright, Pat Cardi as Gary Reed, and Michael Shea as Rick.