Thermal amplitude or thermal range refers to the temperature range in which a cold autoantibody or cold-reacting alloantibody binds to its antigen.[1][2] Cold antibodies that can bind to antigen above 30 °C (86 °F) are considered potentially clinically significant and may lead to disease that occurs or worsens on exposure to low temperatures.[2][3] The closer the thermal range comes to core body temperature (37 °C or 99 °F), the greater the chance that the antibody will cause symptoms such as anemia or Raynaud syndrome.[1][3] Antibodies that are only reactive at temperatures below 30 °C (86 °F) are generally considered unlikely to be clinically significant.[1]

References

  1. 1 2 3 "Glossary: Thermal Range". Blood Bank Guy. 2019-02-06. Retrieved 2019-02-15.
  2. 1 2 Hopkins, C; Walters, TK (2013). "Thermal amplitude test". Immunohematology. 29 (2): 49–50. doi:10.21307/immunohematology-2019-123. ISSN 0894-203X. PMID 24094235. S2CID 19377876.
  3. 1 2 Gupta, V (2014). "Assessment of Red Blood Cell Parameters and Peripheral Smear at Different Temperatures in Case of Cold Agglutination Disease". Annals of Medical and Health Sciences Research. 4 (Suppl 1): S25–S28. doi:10.4103/2141-9248.131703. ISSN 2141-9248. PMC 4083734. PMID 25031901.


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