Transmembrane Protein 205 (TMEM205) is a protein encoded on chromosome 19 by the TMEM205 gene.

TMEM205
Identifiers
AliasesTMEM205, UNQ501, transmembrane protein 205
External IDsOMIM: 613771 MGI: 3045495 HomoloGene: 43895 GeneCards: TMEM205
Orthologs
SpeciesHumanMouse
Entrez

374882

235043

Ensembl

ENSG00000105518

ENSMUSG00000040883

UniProt

Q6UW68

Q91XE8

RefSeq (mRNA)

NM_001253867
NM_001253868
NM_001253869
NM_001253870
NM_178577

RefSeq (protein)

NP_001240796
NP_001240797
NP_001240798
NP_001240799
NP_848692

Location (UCSC)Chr 19: 11.34 – 11.35 MbChr 9: 21.83 – 21.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gene

TMEM205 is located on the minus strand of chromosome 19 from base pair 11,453,452 to 11,456,981. In close proximity to TMEM205, CCDC159 is located slightly upstream and RAB3D slightly down stream of the genomic sequence.

Homology

TMEM205 has no known Paralogs in the Human genome. Using UCSC genome browser BLAT[5] against the human protein sequence it was found that the closest relative to humans to contain a paralog of the TMEM205 gene in its genome is the Bushbaby. TMEM205 does however have a large range of ortholog sequences.

Genus SpeciesOrganism common nameDivergence from humans (MYA)[6]NCBI Protein AccessionSequence similarity[7]Protein length
Homo sapiens[8]Human0AAH91472.1100%189
Pan troglodytes[9]Chimpanzee6.4XP_003316117.1100%189
Pongo pygmaeus[10]Orangutan15.8NP 001124814.199%189
Gorilla gorilla[11]Gorilla8.8XP_004060075.199%189
Callithrix jacchus[12]Common Marmoset43.9XP_002761800.196%189
Mus musculus[13]Mouse94.1BAA92792764.188%189
Sarcophilus harrisii[14]Tasmanian Devil162.6XP_003760487.177%193
Crotalus adamanteus[15]Rattle Snake296AFJ51753.185%188
Xenopus[16]Xenopus371NP_001037942.168%189

Protein

The human homologue of TMEM205 is 189 amino acids long and has a molecular weight of 21.2 kDa. It contains 4 hydrophobic helical domains that are predicted to be transmembrane domains.

Expression

TMEM205 has been shown to be expressed in greater amounts in tissues that have secretory function. These tissues include the thyroid, adrenal gland, pancrease, and mammary tissues.[17] The protein has also been shown to have increased expression in tumor tissue that have become resistant to platinum based chemotherapy drugs.

Function

TMEM205 is thought to be a multi-pass transmembrane protein. It has been shown to be located at the plasma membrane in humans tissues and translocates to the nuclear envelope when cells become resistant to Cisplatin.[17] It contains four domains predicted to be trans membrane domains by TMHMM analysis.

Interacting proteins

TMEM205 has been shown to be co-located with RAB8 a known GTPase involved in vesicular traffic.[18]

Clinical significance

TMEM205 has been shown to be involved in Cisplatin resistance. Cisplatin is a chemotherapeutic drug that is commonly used to treat solid malignancies such as carcinomas, sarcomas, and lymphomas. In addition to being involved in Cisplatin resistance there is growing evidence that the protein is also involved in the diseases thyroiditis and prostatitis

Notes

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000105518 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040883 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Kent WJ (April 2002). "BLAT--the BLAST-like alignment tool". Genome Research. 12 (4): 656–64. doi:10.1101/gr.229202. PMC 187518. PMID 11932250.
  6. ↑ "Time Tree".
  7. ↑ "NCBI BLAST".
  8. ↑ "NCBI Protein: AAH91472.1".
  9. ↑ "NCBI Protein: XP_003316117.1".
  10. ↑ "NCBI Protein: NP_001124814.1".
  11. ↑ "NCBI Protein: XP_004060075.1".
  12. ↑ "NCBI Protein: XP_002761800.1".
  13. ↑ "NCBI Protein: BAA92792764.1".
  14. ↑ "NCBI Nucleotide: XP_003760487.1".
  15. ↑ "NCBI Nucleotide: AFJ51753.1".
  16. ↑ "NCBI Nucleotide: NP_001037942.1".
  17. 1 2 Shen DW, Ma J, Okabe M, Zhang G, Xia D, Gottesman MM (November 2010). "Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance". Journal of Cellular Physiology. 225 (3): 822–8. doi:10.1002/jcp.22287. PMC 2971691. PMID 20589834.
  18. ↑ Shen DW, Gottesman MM (March 2012). "RAB8 enhances TMEM205-mediated cisplatin resistance". Pharmaceutical Research. 29 (3): 643–50. doi:10.1007/s11095-011-0562-y. PMC 3288766. PMID 21969054.
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