Left panel

The left panel portrays the legendary flight and the fall of St. Anthony. In the sky, the saint is brought down by a host of demons. Below, is the saint's grotto (or a brothel), carved within a hill in the shape of a man on all fours, whose backside forms the entrance. An impious procession is directed towards the latter, led by a demon wearing holy vestments and by a deer. In the foreground is a tired-out Anthony, supported after the fall by a monk and a layman; the latter has been traditionally identified as Bosch himself.

Under the bridge which crosses an icy lake are three figures, one of which is a monk reading a letter. Also on the lake is a demon bird with skates: its beak holds a cartouche with the word "fat". This could be a reference to the simony scandal.

Detail of the central panel including the man in a top hat

Detail of the right panel showing the table of luxury

Central panel

The center panel exemplifies Bosch's attraction to the saintly ability of refusing temptation. It depicts the temptation of St. Anthony scene proper. At the center is the saint in contemplation, with a blessing hand pointing at his small cell inside a ruined tower where a miniature Christ appears to point at the Crucifix, to suggest the true sacrifice in reply to the profanatory mass celebrated by demons and priestess at his left. A black-skinned priestess holds a vessel with a toad, a symbol of witchcraft as well as of luxury; the animal in turns holds an egg. A black-dressed singer has a pig face and a little owl (an allegory of heresy) above his head, while a crippled man is going to receive the communion. The saint looks out into the world while pointing in the direction of Christ; no one in the panel (world) is looking in His direction.

The background shows, at left, a city on fire, a traditional symbol of the protection granted by Anthony against ergotism and fire.^[1][6] The monks of the Order of St. Anthony specialized in the treatment and care of victims of ergotism (also known as St. Anthony's fire), who experienced burning sensations and hallucinations.

The demon group at the left, including a woman wearing a helmet resembling a hollow tree, may symbolize the bloody violence. The group in the water at right may be a devilish parody of either the flight into Egypt or the Adoration of the Magi; a third demonic group is that getting out from the red fruit in the foreground. This include a devil who is playing a harp, riding a chicken, and another moving around the fish-boat at the center.

In the sky are a ship-shaped bird, flying fish and winged boats. Finally, the bearded man with a top hat could be the wizard who has set up the whole visions package.^[1]

In another interpretation, much of the images relate to ergotism and the forms of treatment at the time of Bosch. The large fruit can be interpreted as a mandrake apple and the man wielding the sword can be seen as a reference to the uprooting ceremony. Mandrake root was used often as a protection against ergotism, and the fruit was used as an anesthetic, which helped with necessary amputations resulting from disease. The natural anesthetic also could kill the patients if given too much, and it also caused hallucinations of its own in addition to the hallucinations of ergotism, giving meaning to the violent nature of the characters surrounding the fruit in the panel. The images of fish and thistle relate to alchemy from the time and other 'cold' elements used to counter the 'hot' malady.^[7]

Right panel

The closed triptych showing the Arrest of Christ and Christ carrying the cross

The right panel depicts the Contemplation of St. Anthony. The two figures riding the fish in the sky had, according to the legend, obtained the capability to fly by the Devil in order to partake in Witches' Sabbaths.

In the foreground is a naked woman, a symbol of luxury.^[1] She is peeping from a hollow trunk through a tent, which is being kept open for her by a toad. Her tempting body is being offered to the saint, who is portrayed at right, contemplating while looking at the observer at the same time. The dwarf next to him, who wears a red mantle and a whirligig, is a symbol of humanity's fecklessness. In the foreground, finally, are the last temptations: a table with bread and a jar of vine, supported by naked demons. One of the human pillars has his foot caught in a jar — an allusion to the sexual act.^[8]

The background includes a towered city, windmills and a lake.

Shutters

As usual in other similar Flemish works of the time, the exteriors of the shutters are painted in grisaille. By tradition, in many churches artworks are covered, and altarpieces with wings are closed in the week before Easter. The subdued coloration and the subject matter of the shutter exteriors of this triptych are in keeping with the Lenten theme.

The left panel shows the Arrest of Christ, including, in the foreground, St. Peter cutting Malchus's ear and, in the background, the soldiers are surrounding a fallen Jesus; at the left is Judas fleeing after his kiss.^[1]

The right panel portrays Christ Carrying the Cross in the background, while the foreground depicts the two thieves, one confessing and the other refusing to convert. Around Jesus is a crowd, in which figures such as Simon of Cyrene, who is supporting the cross, and the Veronica, can be identified.^[1]