Tsukushi (protein)

TSKU
Identifiers
Aliases	TSKU, E2IG4, LRRC54, TSK, tsukushi, small leucine rich proteoglycan
External IDs	OMIM: 608015 MGI: 2443855 HomoloGene: 41045 GeneCards: TSKU
Gene location (Human)
Chr.	Chromosome 11 (human)
End	76,798,153 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	98,010,535 bp
RNA expression pattern
	Top expressed in
	canal of the cervix; ; left uterine tube; ; gastric mucosa; ; right lobe of liver; ; subcutaneous adipose tissue; ; vagina; ; skin of abdomen; ; tibial nerve; ; vena cava; ; vulva;
	Top expressed in
	gallbladder; ; respiratory epithelium; ; olfactory epithelium; ; lip; ; ankle joint; ; duodenum; ; superior surface of tongue; ; esophagus; ; corneal stroma; ; yolk sac;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity;
Cellular component	extracellular region; extracellular space; plasma membrane;
Biological process	anterior commissure morphogenesis; regulation of gene expression; negative regulation of Wnt signaling pathway; corpus callosum morphogenesis; camera-type eye development; ciliary body morphogenesis; lateral ventricle development; adenylate cyclase-modulating G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	25987
	244152
	ENSG00000182704
	ENSMUSG00000049580
	Q8WUA8
	Q8CBR6
	NM_001258210; NM_015516; NM_001318477; NM_001318478; NM_001318479
	NM_001024619; NM_001168539; NM_001168540; NM_001168541
	NP_001245139; NP_001305406; NP_001305407; NP_001305408; NP_056331
	NP_001019790; NP_001162011; NP_001162012; NP_001162013
	Wikidata
View/Edit Human	View/Edit Mouse

Tsukushi or tsukushin is an extracellular matrix protein of the small leucine rich proteoglycan (SLRP) family. In humans it is encoded by the TSKU gene.^[5]

Tsukushi is a non-canonical class IV SLRP.^[6] It is involved in early animal development.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000182704 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049580 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Tsukushi, small leucine rich proteoglycan". Retrieved 2018-02-01.
↑ Iozzo, Renato V.; Schaefer, Liliana (March 2015). "Proteoglycan form and function: A comprehensive nomenclature of proteoglycans". Matrix Biology. 42: 11–55. doi:10.1016/j.matbio.2015.02.003. PMC 4859157. PMID 25701227.
↑ Ohta, Kunimasa; Lupo, Giuseppe; Kuriyama, Sei; Keynes, Roger; Holt, Christine E.; Harris, William A.; Tanaka, Hideaki; Ohnuma, Shin-ichi (September 2004). "Tsukushi Functions as an Organizer Inducer by Inhibition of BMP Activity in Cooperation with Chordin". Developmental Cell. 7 (3): 347–358. doi:10.1016/j.devcel.2004.08.014. PMC 3793302. PMID 15363410.

References

Further reading